PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26227222-10	2016	Collectively, our results indicated that the proteasome inhibitor bortezomib and the TAK1 inhibitor 5Z-7-oxozeaenol displayed synergy on inhibiting BL cell apoptosis by inhibiting NF-kappaB activity.	5-7-oxo-zeaenol	100-115	nuclear factor kappa B subunit 1	Homo sapiens	180-189	
26687627-7	2016	The results also suggested that TAK1 inhibitor (5Z-7-oxozeaenol) could inhibit AGEs-induced macrophage activation to down-regulate inflammatory cytokine production via MAPKs and NF-kappaB pathways, indicating that 5Z-7-oxozeaenol might be an immunoregulatory agent against AGEs-stimulated inflammatory response in DN.	5-7-oxo-zeaenol	48-63	nuclear factor kappa B subunit 1	Homo sapiens	178-187	
26687627-7	2016	The results also suggested that TAK1 inhibitor (5Z-7-oxozeaenol) could inhibit AGEs-induced macrophage activation to down-regulate inflammatory cytokine production via MAPKs and NF-kappaB pathways, indicating that 5Z-7-oxozeaenol might be an immunoregulatory agent against AGEs-stimulated inflammatory response in DN.	5-7-oxo-zeaenol	214-229	nuclear factor kappa B subunit 1	Homo sapiens	178-187	
20200282-7	2010	Blocking TAK1 kinase activity with a highly selective inhibitor (5z-7-oxozeaenol) attenuated the phosphorylation of nuclear and cytoplasmic IKKalpha/beta, IkappaB-alpha, and RelA, and also impaired IkappaB-alpha degradation and NF-kappaB DNA binding in activated neutrophils.	5-7-oxo-zeaenol	65-80	nuclear factor kappa B subunit 1	Homo sapiens	228-237	
26823762-9	2015	In vitro, 5Z-7-oxozeaenol, a selective TAK1 inhibitor, significantly inhibited the proliferation and invasion and promoted the apoptosis of thyroid cancer cells, possibly due to its inhibition of the activation of the nuclear factor-kappaB (NF-kappaB) signaling pathway.	5-7-oxo-zeaenol	10-25	nuclear factor kappa B subunit 1	Homo sapiens	218-239	
26823762-9	2015	In vitro, 5Z-7-oxozeaenol, a selective TAK1 inhibitor, significantly inhibited the proliferation and invasion and promoted the apoptosis of thyroid cancer cells, possibly due to its inhibition of the activation of the nuclear factor-kappaB (NF-kappaB) signaling pathway.	5-7-oxo-zeaenol	10-25	nuclear factor kappa B subunit 1	Homo sapiens	241-250	
22753724-5	2012	RESULTS: Cells treated with (5Z)-7-oxozeaenol exhibited down-regulation of NF-kappaB in a dose-dependent manner.	5-7-oxo-zeaenol	28-45	nuclear factor kappa B subunit 1	Homo sapiens	75-84	
22753724-9	2012	CONCLUSION: Our findings suggest that (5Z)-7-oxozeaenol is a potent inhibitor of the NF-kappaB pathway and potentiates the production of ROS, as well as induces caspase-3 and -7 in HeLa and HT-29 cancer cells.	5-7-oxo-zeaenol	38-55	nuclear factor kappa B subunit 1	Homo sapiens	85-94	
22753698-3	2012	The effects of (5Z)-7-oxozeaenol on the expression of the nuclear factor kappa B (NF-kappaB) p65, p50, IkappaB kinase (IKKalpha), IKKbeta and caspase-7 were analyzed by western blot.	5-7-oxo-zeaenol	15-32	nuclear factor kappa B subunit 1	Homo sapiens	58-80	
22753698-3	2012	The effects of (5Z)-7-oxozeaenol on the expression of the nuclear factor kappa B (NF-kappaB) p65, p50, IkappaB kinase (IKKalpha), IKKbeta and caspase-7 were analyzed by western blot.	5-7-oxo-zeaenol	15-32	nuclear factor kappa B subunit 1	Homo sapiens	82-91	
22753698-6	2012	RESULTS: (5Z)-7-Oxozeaenol down-regulated NF-kappaB in a dose-dependent manner.	5-7-oxo-zeaenol	9-26	nuclear factor kappa B subunit 1	Homo sapiens	42-51	
22753698-11	2012	CONCLUSION: Our findings suggest that (5Z)-7-oxozeaenol is a potent up-stream inhibitor of the NF-kappaB pathway, enhances the sensitivity of treated cells to apoptosis induced by ROS, and affects cell adhesion of MDA-MB-231 breast cancer cells.	5-7-oxo-zeaenol	38-55	nuclear factor kappa B subunit 1	Homo sapiens	95-104	
12624112-5	2003	In cell culture, 5Z-7-oxozeaenol blocked interleukin-1-induced activation of TAK1, JNK/p38 MAPK, IkappaB kinases, and NF-kappaB, resulting in inhibition of cyclooxgenase-2 production.	5-7-oxo-zeaenol	17-32	nuclear factor kappa B subunit 1	Homo sapiens	118-127	
33375627-5	2020	In vitro model, using GBM cell lines, showed that 5Z-7-oxozeaenol augmented the cytotoxic effects of TMZ, blocking TMZ-induced NF-kappaB-activation, reducing DNA-damage and enhancing TMZ-induced apoptosis in GMB cell lines.	5-7-oxo-zeaenol	50-65	nuclear factor kappa B subunit 1	Homo sapiens	127-136