PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32345326-0	2020	CPI-613 rewires lipid metabolism to enhance pancreatic cancer apoptosis via the AMPK-ACC signaling.	devimistat	0-7	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	80-84	
32345326-7	2020	RESULTS: CPI-613 exhibits anticancer activity in pancreatic cancer cells by triggering ROS-associated apoptosis, which is accompanied by increased autophagy and repressed lipid metabolism through activating the AMPK signaling.	devimistat	9-16	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	211-215	
32345326-8	2020	Intriguingly, ACC, the key enzyme modulating lipid metabolism, is identified as a vital target of CPI-613, which is inactivated in an AMPK-dependent manner and influences apoptotic process upon CPI-613.	devimistat	98-105	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	134-138	
32345326-9	2020	Blockade or enhancement of autophagic process does not increase or blunt apoptosis to CPI-613, but inhibition of the AMPK-ACC signaling significantly attenuates apoptosis induced by CPI-613, suggesting CPI-613-mediated lipid metabolism reduction contributes to its cytotoxicity in pancreatic cancer cells.	devimistat	182-189	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	117-121	
32345326-9	2020	Blockade or enhancement of autophagic process does not increase or blunt apoptosis to CPI-613, but inhibition of the AMPK-ACC signaling significantly attenuates apoptosis induced by CPI-613, suggesting CPI-613-mediated lipid metabolism reduction contributes to its cytotoxicity in pancreatic cancer cells.	devimistat	182-189	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	117-121	
32345326-10	2020	CONCLUSIONS: These findings explore the critical role of lipid metabolism in apoptosis, providing new insights into the AMPK-ACC signaling axis in crosstalk between lipid metabolism and apoptosis in CPI-613 treatment.	devimistat	199-206	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	120-124