PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27311540-1 2016 Agomelatine is a novel antidepressant with agonistic actions at melatonergic (MT1 and MT2 receptors) and antagonistic actions at 5HT-2C receptors. agomelatine 0-11 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 129-135 25394903-14 2015 According to our findings, we concluded that agomelatine improves memory deficit and thus improves the effect of agomelatine arises from its 5HT-2C receptor antagonist activity. agomelatine 45-56 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 141-156 25394903-14 2015 According to our findings, we concluded that agomelatine improves memory deficit and thus improves the effect of agomelatine arises from its 5HT-2C receptor antagonist activity. agomelatine 113-124 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 141-156 33156577-7 2021 The antidepressant agomelatine had a similar effect than melatonin when applied alone but blocked the melatonin-promoted Gq activation due to its 5-HT2C antagonistic component. agomelatine 19-30 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 146-152 23768699-7 2013 ), a serotonin 5HT2C agonist, partially attenuated the anticompulsive effect of agomelatine (30 mg/kg). agomelatine 80-91 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 15-20 23768699-12 2013 The results indicate that agomelatine has a potent anticompulsive effect that can be attributed to 5HT2C antagonism and MT1/2 agonism, and is certainly not mediated via its effects on the GABAergic system. agomelatine 26-37 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 99-104