PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33879070-8	2021	Irbesartan also increased the expression of IL-10 and inhibited the expression of TNF-alpha in monocyte culture supernatants in a concentration-dependent manner.	Irbesartan	0-10	tumor necrosis factor	Homo sapiens	82-91	
30356256-7	2018	In addition irbesartan exerts an anti-inflammatory activity reducing Toll-like receptors (TLRs)-2 and -4 mRNA expression, TNF-alpha expression and activity (20%) and increasing the expression of the cytokine IL-17 (40%) (P<0.05 vs hypoxia).	Irbesartan	12-22	tumor necrosis factor	Homo sapiens	122-131	
15210574-7	2004	3 Irbesartan inhibited the production of both tumor necrosis factor-alpha and interferon-gamma by activated T-cells, especially at therapeutic concentrations.	Irbesartan	2-12	tumor necrosis factor	Homo sapiens	46-73	
26400537-5	2015	In this study, we examined whether irbesartan prevents TNF-alpha-induced ICAM-1, VCAM-1, and E-selectin expression in human umbilical vein endothelial cells (HUVECs).	Irbesartan	35-45	tumor necrosis factor	Homo sapiens	55-64	
26400537-9	2015	RESULTS: It indicated that in HUVECs irbesartan inhibited expression and secretion of TNFalpha-induced ICAM-1, VCAM-1, and E-selectin.	Irbesartan	37-47	tumor necrosis factor	Homo sapiens	86-94	
26400537-10	2015	Furthermore, irbesartan inhibited TNF-alpha-induced IkappaB-alpha phosphorylation and NF-kappaB P65 nuclear translocation substantially.	Irbesartan	13-23	tumor necrosis factor	Homo sapiens	34-43	
26400537-11	2015	In conclusion, irbesartan attenuates TNFalpha-induced ICAM-1, VCAM-1, and E-selectin expression by way of suppressing the NF-kappaB pathways in HUVECs.	Irbesartan	15-25	tumor necrosis factor	Homo sapiens	37-45	
26400537-13	2015	CONCLUSIONS: Irbesartan attenuates TNFalpha-induced ICAM-1, VCAM-1 and MCP-1 expression through the suppression of NF-kappaB pathways.	Irbesartan	13-23	tumor necrosis factor	Homo sapiens	35-43	
17345784-0	2006	Telmisartan and irbesartan therapy in type 2 diabetic patients treated with rosiglitazone: effects on insulin-resistance, leptin and tumor necrosis factor-alpha.	Irbesartan	16-26	tumor necrosis factor	Homo sapiens	133-160	
26400537-0	2015	Irbesartan attenuates TNF-alpha-induced ICAM-1, VCAM-1, and E-selectin expression through suppression of NF-kappaB pathway in HUVECs.	Irbesartan	0-10	tumor necrosis factor	Homo sapiens	22-31