PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24649056-0 2013 Inhibition of ubiquitin protein expression and 20S proteasome activity by irbesartan prevents post-infarction ventricular remodeling and decreases TNF-alpha generation. Irbesartan 74-84 tumor necrosis factor Rattus norvegicus 147-156 34358075-0 2021 Protective Effects of Irbesartan, an Angiotensin Receptor Blocker with PPARgamma Agonistic Activity, against Estradiol Benzoate-Induced Endometrial Hyperplasia and Atypia in Female Rats via Modulation of TNFalpha/Survivin Pathway. Irbesartan 22-32 tumor necrosis factor Rattus norvegicus 204-212 31036110-8 2019 Compared with the diabetic model group, FBG, TC, TG and LDL levels, MDA activity, MCP-1, ICAM-1 and TNF- levels all decreased in rats of the irbesartan treatment group (all p <0.001), and both GSH and SOD activity increased (both p<0.001). Irbesartan 142-152 tumor necrosis factor Rattus norvegicus 100-103 24649056-6 2013 The expression of TNF-alpha, ubiquitin protein and 20S proteasome were significantly increased in the MI control group and irbesartan was shown to dose-dependently inhibit the expression of TNF-alpha, ubiquitin protein and 20S proteasome. Irbesartan 123-133 tumor necrosis factor Rattus norvegicus 18-27 24649056-6 2013 The expression of TNF-alpha, ubiquitin protein and 20S proteasome were significantly increased in the MI control group and irbesartan was shown to dose-dependently inhibit the expression of TNF-alpha, ubiquitin protein and 20S proteasome. Irbesartan 123-133 tumor necrosis factor Rattus norvegicus 190-199 24649056-7 2013 In conclusion, it was hypothesized that UPS signaling is involved in ventricular remodeling following MI and the mechanism underlying the effect of irbesartan on ventricular remodeling may be associated with the downregulation of the expression of TNF-alpha, ubiquitin protein and 20S proteasome. Irbesartan 148-158 tumor necrosis factor Rattus norvegicus 248-257 18584585-11 2008 CONCLUSION: Systemic and local administration of irbesartan lowers glomerular expression of TGF-beta1, PDGF-B, VEGF and TNF-alpha. Irbesartan 49-59 tumor necrosis factor Rattus norvegicus 120-129 16193242-3 2005 Since Angiotensin II type 1 (AT1) receptor can be involved in TNF-alpha production, we have investigated whether early short-term treatment with irbesartan, an AT1 receptor blocker, is able to limit TNF-alpha production within the heart and to improve cardiac function and geometry following MI in rats. Irbesartan 145-155 tumor necrosis factor Rattus norvegicus 199-208 16193242-5 2005 On day 7, cardiac TNF-alpha was significantly reduced in MI rats receiving irbesartan (p < 0.05). Irbesartan 75-85 tumor necrosis factor Rattus norvegicus 18-27 11331262-17 2001 TNFalpha levels were decreased in irbesartan-treated rats but not in nifedipine-treated rats. Irbesartan 34-44 tumor necrosis factor Rattus norvegicus 0-8