PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27405250-2	2016	Irbesartan, an angiotensin receptor blocker, possesses partial peroxisome proliferator-activated receptor gamma (PPAR-gamma) agonist activity and increases circulating adiponectin.	Irbesartan	0-10	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	168-179	
21691037-4	2011	Compared with the placebo group, plasma insulin, homeostasis model assessment of insulin resistance index, and plasma triglyceride levels were significantly lower while plasma adiponectin levels were significantly higher in the pioglitazone- and irbesartan-treated groups, but not in the valsartan-treated group.	Irbesartan	246-256	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	176-187	
21691037-5	2011	Significant increases in the gene expression of adiponectin and GLUT4 within adipose tissue were also observed in the pioglitazone- and irbesartan-treated groups, but not in the valsartan-treated group.	Irbesartan	136-146	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	48-59	
33570444-0	2021	The antihypertensive effect of irbesartan in spontaneously hypertensive rats is associated with improvement of the leptin-adiponectin imbalance.	Irbesartan	31-41	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	122-133	
19633450-0	2009	The protective effect of irbesartan in rats fed a high fat diet is associated with modification of leptin-adiponectin imbalance.	Irbesartan	25-35	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	106-117	
19633450-8	2009	The leptin/adiponectin ratio of plasma concentrations and protein expression in lumbar adipose tissue increased (P < 0.05) in HFD rats, and were normalized by irbesartan.	Irbesartan	162-172	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	11-22	
15939809-4	2005	Adiponectin protein expression was markedly stimulated by Ang II (5 nmol/L), which was inhibited by blockade of the AT2R, and further enhanced by the ARB irbesartan.	Irbesartan	154-164	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	0-11	
15939809-5	2005	Irbesartan-mediated adiponectin upregulation started beyond the concentrations needed for AT1R blockade and was also present in the absence of Ang II, implicating an AT1R-independent mechanism of action.	Irbesartan	0-10	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	20-31	
15939809-8	2005	Blockade of PPARgamma activation by the PPARgamma antagonist GW9662 markedly inhibited irbesartan-induced adiponectin expression.	Irbesartan	87-97	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	106-117	
15939809-10	2005	Kinetic studies using the protein synthesis inhibitor cycloheximide showed that irbesartan prevented the cellular depletion of adiponectin protein.	Irbesartan	80-90	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	127-138	
15939809-11	2005	Finally, administration of irbesartan to obese Zucker rats improved insulin sensitivity and attenuated adiponectin serum depletion.	Irbesartan	27-37	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	103-114	
19633450-11	2009	The correction of leptin-adiponectin imbalance may be an important mechanism participating in the protective effect of irbesartan in HFD rats.	Irbesartan	119-129	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	25-36	
34691163-7	2021	Diabetic SHRs pretreated with pioglitazone and adiponectin separately exerted improvements in antioxidant enzyme activities, abrogated arterial stiffness, and offset the increased production of reactive oxygen species and dyslipidemic effects of STZ, whereas the blood pressure values were significantly reduced in the irbesartan-treated groups (all P < 0.05).	Irbesartan	319-329	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	47-58