PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30283089-0 2018 A gender-specific association of the polymorphism Ile197Met in the kininogen 1 gene with plasma irbesartan concentrations in Chinese patients with essential hypertension. Irbesartan 96-106 kininogen 1 Homo sapiens 67-78 30283089-1 2018 This study was conducted to explore interactions in the association of the kininogen (KNG1) Ile197Met polymorphism and gender with plasma concentrations of irbesartan in Chinese patients with essential hypertension. Irbesartan 156-166 kininogen 1 Homo sapiens 86-90 30283089-9 2018 A further test for a multiplicative interaction between the KNG1 Ile197Met polymorphism and gender in association with ln-plasma irbesartan concentrations in a multiple linear regression model was also significant (P for interaction = 0.033). Irbesartan 129-139 kininogen 1 Homo sapiens 60-64 30283089-10 2018 This is the first study to suggest that gender may influence the association of the Ile197Met variant of KNG1 with ln-plasma irbesartan concentration. Irbesartan 125-135 kininogen 1 Homo sapiens 105-109 30283089-11 2018 This finding may indicate that the interaction of gender and the KNG1 Ile197Met gene polymorphism can influence plasma trough irbesartan concentrations, which may contribute to a better development of personalized hypertensive treatment in Chinese patients. Irbesartan 126-136 kininogen 1 Homo sapiens 65-69