PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22100460-0	2012	Beneficial effects of metformin and irbesartan on advanced glycation end products (AGEs)-RAGE-induced proximal tubular cell injury.	Irbesartan	36-46	long intergenic non-protein coding RNA 914	Homo sapiens	89-93	
22100460-3	2012	Further, since a pathophysiological crosstalk between renin-angiotensin system (RAS) and AGEs-RAGE axis is involved in diabetic nephropathy, it is conceivable that metformin and irbesartan additively could protect against the AGEs-RAGE-induced tubular cell injury.	Irbesartan	178-188	long intergenic non-protein coding RNA 914	Homo sapiens	94-98	
22100460-3	2012	Further, since a pathophysiological crosstalk between renin-angiotensin system (RAS) and AGEs-RAGE axis is involved in diabetic nephropathy, it is conceivable that metformin and irbesartan additively could protect against the AGEs-RAGE-induced tubular cell injury.	Irbesartan	178-188	long intergenic non-protein coding RNA 914	Homo sapiens	231-235	
22100460-8	2012	Our present study suggests that combination therapy with metformin and irbesartan may have therapeutic potential in diabetic nephropathy; it could play a protective role against tubular injury in diabetes not only by inhibiting AGEs formation, but also by attenuating the deleterious effects of AGEs via down-regulating RAGE expression and subsequently suppressing ROS generation.	Irbesartan	71-81	long intergenic non-protein coding RNA 914	Homo sapiens	320-324