PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31828866-9 2020 Moreover, Scu reduced hepatocyte steatosis, decreased lipid accumulation and triglyceride levels, inhibited mTOR phosphorylation, and decreased the SREBP-1c level in the liver. scutellarin 10-13 sterol regulatory element binding transcription factor 1 Homo sapiens 148-156 31828866-0 2020 Scutellarin, a modulator of mTOR, attenuates hepatic insulin resistance by regulating hepatocyte lipid metabolism via SREBP-1c suppression. scutellarin 0-11 sterol regulatory element binding transcription factor 1 Homo sapiens 118-126 31828866-7 2020 Moreover, Scu downregulated mammalian target of rapamycin (mTOR) phosphorylation and the n-SREBP-1c protein level and also reduced lipid accumulation via the mTOR-dependent pathway, as confirmed by the molecular docking of Scu to mTOR. scutellarin 10-13 sterol regulatory element binding transcription factor 1 Homo sapiens 91-99 34859513-4 2022 Scu reduced intracellular lipid content and inhibited sterol regulatory element binding protein-1c (SREBP-1c)-mediated lipid synthesis and fatty acid translocase-mediated lipid uptake in HepG2 cells. scutellarin 0-3 sterol regulatory element binding transcription factor 1 Homo sapiens 54-98 34859513-4 2022 Scu reduced intracellular lipid content and inhibited sterol regulatory element binding protein-1c (SREBP-1c)-mediated lipid synthesis and fatty acid translocase-mediated lipid uptake in HepG2 cells. scutellarin 0-3 sterol regulatory element binding transcription factor 1 Homo sapiens 100-108 31828866-10 2020 Taken together, these findings suggest that Scu ameliorates hepatic IR by regulating hepatocyte lipid metabolism via the mTOR-dependent pathway through SREBP-1c suppression. scutellarin 44-47 sterol regulatory element binding transcription factor 1 Homo sapiens 152-160