PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33919246-6	2021	Moreover, we found that Costunolide, a TERT inhibitor, was effective in reducing the cell viability in vitro of both primary tumor models as well as tumor models pre-treated with chemotherapy and radiotherapy.	costunolide	24-35	telomerase reverse transcriptase	Homo sapiens	39-43	
27148686-2	2016	Pharmacological inhibition of human Telomerase reverse transcriptase (hTERT) by Costunolide induced glioma cell apoptosis in a reactive oxygen species (ROS)-dependent manner.	costunolide	80-91	telomerase reverse transcriptase	Homo sapiens	70-75	
27148686-6	2016	Inhibition of hTERT either by Costunolide, or by siRNA or dominant-negative hTERT (DN-hTERT) abrogated (i) expression of Glucose-6-phosphate dehydrogenase (G6PD) and Transketolase (TKT) - two major nodes in the pentose phosphate (PPP) pathway; and (ii) phosphorylation of glycogen synthase (GS).	costunolide	30-41	telomerase reverse transcriptase	Homo sapiens	14-19	
18451540-7	2008	Telomerase activity was significantly suppressed after treatment with costunolide, and human telomerase reverse transcriptase (hTERT), a critical determinant of the enzyme activity of telomerase, decreased the expression of both mRNA and protein levels by costunolide.	costunolide	70-81	telomerase reverse transcriptase	Homo sapiens	93-125	
18451540-7	2008	Telomerase activity was significantly suppressed after treatment with costunolide, and human telomerase reverse transcriptase (hTERT), a critical determinant of the enzyme activity of telomerase, decreased the expression of both mRNA and protein levels by costunolide.	costunolide	70-81	telomerase reverse transcriptase	Homo sapiens	127-132	
18451540-7	2008	Telomerase activity was significantly suppressed after treatment with costunolide, and human telomerase reverse transcriptase (hTERT), a critical determinant of the enzyme activity of telomerase, decreased the expression of both mRNA and protein levels by costunolide.	costunolide	256-267	telomerase reverse transcriptase	Homo sapiens	93-125	
18451540-7	2008	Telomerase activity was significantly suppressed after treatment with costunolide, and human telomerase reverse transcriptase (hTERT), a critical determinant of the enzyme activity of telomerase, decreased the expression of both mRNA and protein levels by costunolide.	costunolide	256-267	telomerase reverse transcriptase	Homo sapiens	127-132	
18451540-9	2008	These data suggest that one of the costunolide-induced apoptotic mechanisms is that the receptor-mediated pathway precedes the mitochondria-dependent pathway, caused by the inhibition of telomerase activity via suppression of hTERT in NALM-6 cells.	costunolide	35-46	telomerase reverse transcriptase	Homo sapiens	226-231	
16112418-5	2005	In addition, the bindings of transcription factors in hTERT promoters were significantly decreased in both cells by the treatment of costunolide.	costunolide	133-144	telomerase reverse transcriptase	Homo sapiens	54-59