PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33102517-2 2020 RCC1 combines with chromatin and Ran to establish a concentration gradient of RanGTP, thereby participating in a series of cell physiological activities. rangtp 78-84 regulator of chromosome condensation 1 Homo sapiens 0-4 30565836-2 2019 This involves the direct action of RanGTP, which is generated in the nucleus by the chromatin-associated nucleotide exchange factor, RCC1. rangtp 35-41 regulator of chromosome condensation 1 Homo sapiens 133-137 17761537-7 2007 Sorbitol stress also slowed RCC1 mobility in the nucleus, which is predicted to reduce RCC1 dissociation from chromatin and RanGTP production. rangtp 124-130 regulator of chromosome condensation 1 Homo sapiens 28-32 23434370-6 2013 Inhibition of MRN function in mammalian cells triggers a metaphase delay and disrupts the RCC1-dependent RanGTP gradient. rangtp 105-111 regulator of chromosome condensation 1 Homo sapiens 90-94 23319601-5 2013 The overexpression of RCC1, the guanine nucleotide exchange factor for Ran, induced steeper mitotic RanGTP gradients in HFF-1 cells, showing the critical role of RCC1 levels in the regulation of mitosis by Ran. rangtp 100-106 regulator of chromosome condensation 1 Homo sapiens 22-26 20465562-3 2010 In this study, using the temperature-sensitive RCC1 mutant tsBN2, a baby hamster kidney 21 cell line, we found that a lack of RCC1 activity inhibited NPC formation during interphase, suggesting that RanGTP is required for NPC formation during interphase in mammalian cells. rangtp 199-205 regulator of chromosome condensation 1 Homo sapiens 126-130 18712773-5 2008 We found that actinomycin D reduced the binding affinity of RCC1 to the mitotic chromosome, which led to a reduction of RanGTP level. rangtp 120-126 regulator of chromosome condensation 1 Homo sapiens 60-64 19060893-2 2009 We have found that the nuclear RanGTP level is diminished during the early stages of apoptosis, which correlates with immobilization of RCC1 on the chromosomes. rangtp 31-37 regulator of chromosome condensation 1 Homo sapiens 136-140 19060893-6 2009 Therefore, we propose that RCC1 reads the histone code created by caspase-activated Mst1 to initiate apoptosis by reducing the level of RanGTP in the nucleus. rangtp 136-142 regulator of chromosome condensation 1 Homo sapiens 27-31 15014043-0 2004 Phosphorylation of RCC1 in mitosis is essential for producing a high RanGTP concentration on chromosomes and for spindle assembly in mammalian cells. rangtp 69-75 regulator of chromosome condensation 1 Homo sapiens 19-23 15014043-4 2004 This phosphorylation is necessary for RCC1 to generate RanGTP on mitotic chromosomes in mammalian cells, which in turn is required for spindle assembly and chromosome segregation. rangtp 55-61 regulator of chromosome condensation 1 Homo sapiens 38-42 15014043-5 2004 Moreover, phosphorylation of the NLS of RCC1 is required to prevent the binding of importin alpha and beta to RCC1, thereby allowing RCC1 to couple RanGTP production to chromosome binding. rangtp 148-154 regulator of chromosome condensation 1 Homo sapiens 40-44 15014043-5 2004 Moreover, phosphorylation of the NLS of RCC1 is required to prevent the binding of importin alpha and beta to RCC1, thereby allowing RCC1 to couple RanGTP production to chromosome binding. rangtp 148-154 regulator of chromosome condensation 1 Homo sapiens 110-114 15014043-5 2004 Moreover, phosphorylation of the NLS of RCC1 is required to prevent the binding of importin alpha and beta to RCC1, thereby allowing RCC1 to couple RanGTP production to chromosome binding. rangtp 148-154 regulator of chromosome condensation 1 Homo sapiens 110-114 12604592-0 2003 A mechanism of coupling RCC1 mobility to RanGTP production on the chromatin in vivo. rangtp 41-47 regulator of chromosome condensation 1 Homo sapiens 24-28 12604592-2 2003 Although the chromosome-associated enzyme RCC1 is responsible for RanGTP production, the mechanism of generating and maintaining the RanGTP gradient in vivo remains unknown. rangtp 66-72 regulator of chromosome condensation 1 Homo sapiens 42-46 12604592-4 2003 Our kinetic modeling suggests that RCC1 couples its catalytic activity to chromosome binding to generate a RanGTP gradient. rangtp 107-113 regulator of chromosome condensation 1 Homo sapiens 35-39 12604592-7 2003 Successful nucleotide exchange dissociates the binary complex, permitting the release of RCC1 and RanGTP from the chromatin and the production of RanGTP on the chromatin surface. rangtp 146-152 regulator of chromosome condensation 1 Homo sapiens 89-93 12606574-3 2003 The steepness of the RanGTP gradient appears limited by both the cytoplasmic RanGAP concentration and the imperfect retention of nuclear RanGTP by nuclear pore complexes (NPCs), but not by the nucleotide exchange activity of RCC1. rangtp 21-27 regulator of chromosome condensation 1 Homo sapiens 225-229 10875935-6 2000 RanGTP is produced from RanGDP through nucleotide exchange mediated by RanGEF (RCC1). rangtp 0-6 regulator of chromosome condensation 1 Homo sapiens 79-83 9351834-2 1997 Ran"s nucleotide-bound state is determined by the chromatin-bound exchange factor RCC1 generating RanGTP in the nucleus and the cytoplasmic GTPase activating protein RanGAP1 depleting RanGTP from the cytoplasm. rangtp 98-104 regulator of chromosome condensation 1 Homo sapiens 82-86 9351834-2 1997 Ran"s nucleotide-bound state is determined by the chromatin-bound exchange factor RCC1 generating RanGTP in the nucleus and the cytoplasmic GTPase activating protein RanGAP1 depleting RanGTP from the cytoplasm. rangtp 184-190 regulator of chromosome condensation 1 Homo sapiens 82-86