PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21239887-3 2011 Although varenicline was designed to be a high affinity partial agonist of nAChRs containing the alpha4 and beta2 subunits (designated as alpha4beta2*), at higher concentrations it can also act upon alpha3beta2*, alpha6*, alpha3beta4* and alpha7 nAChRs. Varenicline 9-20 immunoglobulin (CD79A) binding protein 1 Mus musculus 97-103 21239887-5 2011 We found that activation of alpha4* nAChRs was necessary and sufficient for varenicline-induced reduction of alcohol consumption. Varenicline 76-87 immunoglobulin (CD79A) binding protein 1 Mus musculus 28-34 29671814-3 2018 In this study, we investigated whether varenicline, a partial α4β2*nAChR agonist which reduces nicotine, alcohol and sucrose consumption, can reduce stress, a driving factor in substance use disorders. Varenicline 39-50 immunoglobulin (CD79A) binding protein 1 Mus musculus 67-74