PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31519584-0 2019 Brexpiprazole Reduces Survivin and Reverses EGFR Tyrosine Kinase Inhibitor Resistance in Lung and Pancreatic Cancer. brexpiprazole 0-13 baculoviral IAP repeat-containing 5 Mus musculus 22-30 31519584-2 2019 Recently, brexpiprazole, an antipsychotic drug, was reported to chemosensitize glioma cells to osimertinib, a third-generation EGFR-TKI, by suppressing survivin, an anti-apoptotic protein, but their combinational effects on lung and pancreatic cancers remain unknown. brexpiprazole 10-23 baculoviral IAP repeat-containing 5 Mus musculus 152-160 31191825-8 2019 In the cancer cells and the CSCs, brexpiprazole reduced the expression of survivin, an anti-apoptotic protein, whose reduction sensitizes tumor cells to chemotherapeutic reagents. brexpiprazole 34-47 baculoviral IAP repeat-containing 5 Mus musculus 74-82 31191825-9 2019 In the preclinical model in which pancreatic CSCs were subcutaneously implanted into nude mice, brexpiprazole suppressed tumor growth, in addition to reducing the expression of Sox2, a marker for CSCs, and survivin. brexpiprazole 96-109 baculoviral IAP repeat-containing 5 Mus musculus 206-214