PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15635176-6	2005	FK228 disappearance activities in human liver microsomes from 12 individuals strongly correlated (r2=0.957) with testosterone 6beta-hydroxylase activities, a marker enzyme activity of CYP3A4/5, but not with other P450 enzyme-specific activities (CYP1A2, 2A6, 2C8, 2C9, 2C19, 2D6, and 4A).	romidepsin	0-5	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	184-190	
15635176-7	2005	Among 14 recombinant heterologously expressed human P450s examined, CYP3A4 exhibited the highest activity of FK228 disappearance.	romidepsin	109-114	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	68-74	
15635176-10	2005	In addition, FK228 disappearance in human liver microsomes was markedly inhibited by ketoconazole, a potent CYP3A4 inhibitor, and an anti-CYP3A4 antibody.	romidepsin	13-18	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	108-114	
15635176-10	2005	In addition, FK228 disappearance in human liver microsomes was markedly inhibited by ketoconazole, a potent CYP3A4 inhibitor, and an anti-CYP3A4 antibody.	romidepsin	13-18	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	138-144	
15635176-11	2005	These results indicate that the metabolism of FK228 in human liver microsomes is catalyzed mainly by CYP3A enzymes, particularly CYP3A4.	romidepsin	46-51	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	129-135