PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32933177-0	2020	Cinobufagin Suppresses Melanoma Cell Growth by Inhibiting LEF1.	cinobufagin	0-11	lymphoid enhancer binding factor 1	Homo sapiens	58-62	
32933177-5	2020	A luciferase assay-based high throughput screening (HTS) with a natural compound library showed that cinobufagin suppressed beta-catenin/TCF4 transcriptional activity by inhibiting LEF1 expression.	cinobufagin	101-112	lymphoid enhancer binding factor 1	Homo sapiens	181-185	
32933177-7	2020	Cinobufagin sensitively attenuates cell viability and induces apoptosis in LEF1 expressing melanoma cells compared to LEF1-low expressing lung cancer cells.	cinobufagin	0-11	lymphoid enhancer binding factor 1	Homo sapiens	75-79	
32933177-8	2020	In addition, ectopic LEF1 expression is sufficient to attenuate cinobufagin-induced apoptosis and cell growth retardation in melanoma cells.	cinobufagin	64-75	lymphoid enhancer binding factor 1	Homo sapiens	21-25	
32933177-9	2020	Thus, we suggest that cinobufagin is a potential anti-melanoma drug that suppresses tumor-promoting Wnt/beta-catenin signaling via LEF1 inhibition.	cinobufagin	22-33	lymphoid enhancer binding factor 1	Homo sapiens	131-135