PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31301417-12	2019	In addition, treatment with cinobufagin could dramatically increase the expression of ROS and then activate the phosphorylation of MAPK family proteins, including ERK 1/2, JNK and p38.	cinobufagin	28-39	mitogen-activated protein kinase 1	Homo sapiens	180-183	
31301417-13	2019	What"s more, the reaction of apoptosis and autophagy induced by cinobufagin treatment could be reversed by p38 inhibitor SB203580 and JNK inhibitor SP600125 as well as ROS exclusive inhibitor antioxidant N-acetyl cysteine (NAC).	cinobufagin	64-75	mitogen-activated protein kinase 1	Homo sapiens	107-110	
25982794-7	2015	Inhibition of ROS generation by N-acetyl-l-cysteine (NAC) significantly prevented CBG-induced ERK, JNK and p38 MAPK activation and apoptosis.	cinobufagin	82-85	mitogen-activated protein kinase 1	Homo sapiens	94-97	
25982794-7	2015	Inhibition of ROS generation by N-acetyl-l-cysteine (NAC) significantly prevented CBG-induced ERK, JNK and p38 MAPK activation and apoptosis.	cinobufagin	82-85	mitogen-activated protein kinase 1	Homo sapiens	111-115	
25982794-9	2015	Interestingly, ERK, JNK and p38MAPK pharmacological inhibitors blocked CBG-induced MAPKs activation and ERK inhibitor (PD98059) also prevented the CBG-induced caspase-3 activation and PARP cleavage in U266 cells.	cinobufagin	71-74	mitogen-activated protein kinase 1	Homo sapiens	15-18	
25982794-4	2015	We found that CBG caused the significant activation of ERK, JNK and p38 MAPK in U266 cells.	cinobufagin	14-17	mitogen-activated protein kinase 1	Homo sapiens	55-58	
25982794-9	2015	Interestingly, ERK, JNK and p38MAPK pharmacological inhibitors blocked CBG-induced MAPKs activation and ERK inhibitor (PD98059) also prevented the CBG-induced caspase-3 activation and PARP cleavage in U266 cells.	cinobufagin	147-150	mitogen-activated protein kinase 1	Homo sapiens	15-18	
25982794-9	2015	Interestingly, ERK, JNK and p38MAPK pharmacological inhibitors blocked CBG-induced MAPKs activation and ERK inhibitor (PD98059) also prevented the CBG-induced caspase-3 activation and PARP cleavage in U266 cells.	cinobufagin	147-150	mitogen-activated protein kinase 1	Homo sapiens	104-107	
25982794-10	2015	Taken together, these findings suggest that CBG can act as a potent anticancer agent against MM and possibly exerts its effects through the ROS-mediated activation of ERK, JNK and p38 MAPK leading to the activation of caspase-3 in U266 cells.	cinobufagin	44-47	mitogen-activated protein kinase 1	Homo sapiens	167-170	
21913902-0	2012	Inhibitory effect of bufalin and cinobufagin on steroidogenesis via the activation of ERK in human adrenocortical cells.	cinobufagin	33-44	mitogen-activated protein kinase 1	Homo sapiens	86-89	
21215801-6	2011	Overexpression of ERK reversed the antiproliferation effect of ouabain or cinobufagin in HepG2 and SMMC-7721 cells.	cinobufagin	74-85	mitogen-activated protein kinase 1	Homo sapiens	18-21	
21215801-4	2011	Ouabain and cinobufagin significantly inhibited cell proliferation by attenuating the phosphorylation of extracellular regulated kinase (ERK) and down-regulating the expression of C-myc.	cinobufagin	12-23	mitogen-activated protein kinase 1	Homo sapiens	105-135	
21215801-4	2011	Ouabain and cinobufagin significantly inhibited cell proliferation by attenuating the phosphorylation of extracellular regulated kinase (ERK) and down-regulating the expression of C-myc.	cinobufagin	12-23	mitogen-activated protein kinase 1	Homo sapiens	137-140