PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30247877-0	2019	Alpha-7 Nicotinic Receptor-Targeted Cinobufagin Induces Antinociception and Inhibits NF-kappaB Signaling Pathway in DRG Neurons.	cinobufagin	36-47	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	0-26	
30247877-4	2019	As shown in the hot-plate test, formalin test, and acetic acid writhing test in mice, administration of CBG produced significant antinociceptive activity in a dose-dependent manner, and the antinociceptive effect was blocked by intraperitoneal pretreatment of methyllycaconitine citrate (an alpha7 nicotinic receptor antagonist) and intrathecal delivery of an alpha7 nicotinic receptor antagonist siRNA (alpha7-siRNA).	cinobufagin	104-107	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	291-316	
30247877-4	2019	As shown in the hot-plate test, formalin test, and acetic acid writhing test in mice, administration of CBG produced significant antinociceptive activity in a dose-dependent manner, and the antinociceptive effect was blocked by intraperitoneal pretreatment of methyllycaconitine citrate (an alpha7 nicotinic receptor antagonist) and intrathecal delivery of an alpha7 nicotinic receptor antagonist siRNA (alpha7-siRNA).	cinobufagin	104-107	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	360-385	
30247877-6	2019	In the chemical pain models and primary cultured DRG neurons, Western blot analysis showed that the formation of p-IkappaB and p-NF-kappaB was regulated by CBG, and the effect of CBG was inhibited by alpha7-siRNA, and ELISA analysis indicated that CBG also regulated the expression of inflammatory cytokines through the alpha7 nicotinic receptor in DRG.	cinobufagin	179-182	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	320-345	
30247877-6	2019	In the chemical pain models and primary cultured DRG neurons, Western blot analysis showed that the formation of p-IkappaB and p-NF-kappaB was regulated by CBG, and the effect of CBG was inhibited by alpha7-siRNA, and ELISA analysis indicated that CBG also regulated the expression of inflammatory cytokines through the alpha7 nicotinic receptor in DRG.	cinobufagin	179-182	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	320-345	
30247877-7	2019	These results suggest that CBG may activate an alpha7 nicotinic receptor, thereby triggering the inhibition of the DRG NF-kappaB signaling pathway, resulting in an antinociceptive effect in mice.	cinobufagin	27-30	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	47-72