PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32113469-0	2020	The spinal microglial IL-10/beta-endorphin pathway accounts for cinobufagin-induced mechanical antiallodynia in bone cancer pain following activation of alpha7-nicotinic acetylcholine receptors.	cinobufagin	64-75	interleukin 10	Rattus norvegicus	22-27	
32113469-7	2020	Intrathecal cinobufagin also stimulated the gene and protein expression of IL-10 and beta-endorphin (but not dynorphin A) in the spinal cords of bone cancer pain rats.	cinobufagin	12-23	interleukin 10	Rattus norvegicus	75-80	
32113469-8	2020	In addition, treatment with cinobufagin in cultured primary spinal microglia but not astrocytes or neurons stimulated the mRNA and protein expression of IL-10 and beta-endorphin, which was prevented by the pretreatment with the IL-10 antibody but not beta-endorphin antiserum.	cinobufagin	28-39	interleukin 10	Rattus norvegicus	153-158	
32113469-8	2020	In addition, treatment with cinobufagin in cultured primary spinal microglia but not astrocytes or neurons stimulated the mRNA and protein expression of IL-10 and beta-endorphin, which was prevented by the pretreatment with the IL-10 antibody but not beta-endorphin antiserum.	cinobufagin	28-39	interleukin 10	Rattus norvegicus	228-233	
32113469-9	2020	Furthermore, spinal cinobufagin-induced mechanical antiallodynia was inhibited by the pretreatment with intrathecal injection of the microglial inhibitor minocycline, IL-10 antibody, beta-endorphin antiserum and specific mu-opioid receptor antagonist CTAP.	cinobufagin	20-31	interleukin 10	Rattus norvegicus	167-172	
32113469-10	2020	Lastly, cinobufagin- and the specific alpha-7 nicotinic acetylcholine receptor (alpha7-nAChR) agonist PHA-543613-induced microglial gene expression of IL-10/beta-endorphin and mechanical antiallodynia in bone cancer pain were blocked by the pretreatment with the specific alpha7-nAChR antagonist methyllycaconitine.	cinobufagin	8-19	interleukin 10	Rattus norvegicus	151-156	
32113469-11	2020	CONCLUSIONS: Our results illustrate that cinobufagin produces mechanical antiallodynia in bone cancer pain through spinal microglial expression of IL-10 and subsequent beta-endorphin following activation of alpha7-nAChRs.	cinobufagin	41-52	interleukin 10	Rattus norvegicus	147-152