PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27845066-0	2017	Cinobufagin induces apoptosis of osteosarcoma cells through inactivation of Notch signaling.	cinobufagin	0-11	notch 1	Mus musculus	76-81	
27845066-6	2017	The involvement of Notch signaling in Cinobufagin-induced apoptosis was confirmed using gain and loss-of function assays.	cinobufagin	38-49	notch 1	Mus musculus	19-24	
27845066-9	2017	Cinobufagin treatment decreased the expression of Notch-1, and Hes-1, Hes-5 and Hey-1 gene expression in OS cell lines.	cinobufagin	0-11	notch 1	Mus musculus	50-57	
27845066-10	2017	Furthermore, Notch activation attenuated the Cinobufagin-induced apoptosis, while Notch inhibition enhanced this effect.	cinobufagin	45-56	notch 1	Mus musculus	13-18	
27845066-13	2017	Taken together, our data suggested that Cinobufagin inhibited cell survival and induced apoptosis in OS cells both in vitro and in vivo, and these effects were partly mediated through the Notch pathway.	cinobufagin	40-51	notch 1	Mus musculus	188-193