PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12620660-1 2003 Several heteroaromatic analogues of (2-aryl-1-cyclopentenyl-1-alkylidene)-(arylmethyloxy)amine COX-2 inhibitors, in which the cyclopentene moiety was replaced by pyrazole, thiophene or isoxazole ring, were synthesized, in order to verify the influence of the different nature of the central core on the COX inhibitory properties of these kinds of molecules. Cyclopentanes 126-138 mitochondrially encoded cytochrome c oxidase II Homo sapiens 95-100 11677234-2 2002 Prostaglandin synthesis by cyclooxygenases-1 and -2 (COX-1 and COX-2) involves an initial oxygenation of arachidonic acid at C-11, followed by endoperoxide and cyclopentane ring formation, and then a second reaction with molecular oxygen in the S configuration at C-15. Cyclopentanes 160-172 mitochondrially encoded cytochrome c oxidase II Homo sapiens 63-68