PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24144307-5 2014 [Flu + Clo + Bu + SAHA] resulted in synergistic cytotoxicity, which can be attributed to (1) activated DNA-damage response and cell cycle checkpoint activation through the ATM-CHK2-P53 (or P73) pathway or ATM-CHK2-cdc25-cdc2 pathway, (2) histone modifications and (3) activated apoptosis pathway. Clofarabine 7-10 cell division cycle 25C Homo sapiens 214-219