PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26819918-0 2015 Clofarabine Has Apoptotic Effect on T47D Breast Cancer Cell Line via P53R2 Gene Expression. Clofarabine 0-11 ribonucleotide reductase regulatory TP53 inducible subunit M2B Homo sapiens 69-74 26819918-2 2015 Clofarabine-induced defect in DNA replication, induces p53 and subsequently P53R2 genes as subunit of RR. Clofarabine 0-11 ribonucleotide reductase regulatory TP53 inducible subunit M2B Homo sapiens 76-81 26819918-3 2015 clofarabine deregulated P53R2 gene expression leading to the elevated levels of P53R2 which impose resistance to DNA damaging drugs. Clofarabine 0-11 ribonucleotide reductase regulatory TP53 inducible subunit M2B Homo sapiens 24-29 26819918-3 2015 clofarabine deregulated P53R2 gene expression leading to the elevated levels of P53R2 which impose resistance to DNA damaging drugs. Clofarabine 0-11 ribonucleotide reductase regulatory TP53 inducible subunit M2B Homo sapiens 80-85 22884950-0 2012 Synergism between clofarabine and decitabine through p53R2: a pharmacodynamic drug-drug interaction modeling. Clofarabine 18-29 ribonucleotide reductase regulatory TP53 inducible subunit M2B Homo sapiens 53-58 22884950-1 2012 Clofarabine (CLO), a purine nucleoside analog with promising efficacy in acute myeloid leukemia (AML), inhibits the ribonucleotidereductase, p53R2. Clofarabine 0-11 ribonucleotide reductase regulatory TP53 inducible subunit M2B Homo sapiens 141-146 22884950-1 2012 Clofarabine (CLO), a purine nucleoside analog with promising efficacy in acute myeloid leukemia (AML), inhibits the ribonucleotidereductase, p53R2. Clofarabine 13-16 ribonucleotide reductase regulatory TP53 inducible subunit M2B Homo sapiens 141-146 22884950-4 2012 These results confirm a role for p53R2 in both CLO and DEC mechanism of action, demonstrate synergism between these two drugs in this AML model and support the use of this combination in a future clinical trial. Clofarabine 47-50 ribonucleotide reductase regulatory TP53 inducible subunit M2B Homo sapiens 33-38 12504799-8 2003 Expression of the recently identified RR subunit, p53R2 full-size protein, in CAFdA cells was low compared to parental cells, but a protein of lower molecular weight was detected in CdA and CAFdA cells. Clofarabine 78-83 ribonucleotide reductase regulatory TP53 inducible subunit M2B Homo sapiens 50-55