PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29901113-12 2018 However, the expression levels of hexokinase 2, phosphoglycerate kinase 1, pyruvate kinase, muscle (PKM)1, PKM2 and lactate dehydrogenase A, which are downstream of RAS and target genes of hypoxia inducible factor-1alpha, were not notably downregulated, which may explain the high concentration of salirasib required to inhibit cell viability. farnesylthiosalicylic acid 298-307 pyruvate kinase M1/2 Homo sapiens 75-105