PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30271499-7 2018 We speculated that the disability of signaling transmission from Ras to c-Raf in COLO-16 cells might contribute to the ineffective performance of salirasib. farnesylthiosalicylic acid 146-155 Raf-1 proto-oncogene, serine/threonine kinase Homo sapiens 72-77 30271499-3 2018 In our study, salirasib treatment led to deregulation of c-Raf, ERK and Akt signaling, blockage of MTOR signaling, interruption on Beclin 1-related autophagy regulation, activation of apoptosis and down-regulation of some cell cycle regulatory proteins in primary human epidermal keratinocyte (HEK)s, but did not exhibit similar effects in the human cSCC cell line COLO-16. farnesylthiosalicylic acid 14-23 Raf-1 proto-oncogene, serine/threonine kinase Homo sapiens 57-62