PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34329582-3 2022 Compared with the other PARPis rucaparib, olaparib, and niraparib, talazoparib displays the highest potency across SCLC, including SLFN11-negative cells. talazoparib 67-78 schlafen family member 11 Homo sapiens 131-137 33536335-4 2021 Accordingly, we validate that clinical inhibitors of ATR (M4344 and M6620) and CHK1 (SRA737) resensitize SLFN11-KO cells to topotecan, indotecan, etoposide, cisplatin, and talazoparib. talazoparib 172-183 schlafen family member 11 Homo sapiens 105-111 27440269-10 2017 We confirmed these findings in vivo across multiple PDX and defined IHC staining for SLFN11 as a predictor of talazoparib response. talazoparib 110-121 schlafen family member 11 Homo sapiens 85-91 27708213-3 2016 Our genomic analyses reveal high correlation between response to talazoparib and Schlafen 11 (SLFN11) expression. talazoparib 65-76 schlafen family member 11 Homo sapiens 81-92 27708213-3 2016 Our genomic analyses reveal high correlation between response to talazoparib and Schlafen 11 (SLFN11) expression. talazoparib 65-76 schlafen family member 11 Homo sapiens 94-100 27708213-5 2016 Response to the talazoparib-temozolomide combination was also driven by SLFN11 and validated in 36 small cell lung cancer cell lines, and in xenograft models. talazoparib 16-27 schlafen family member 11 Homo sapiens 72-78