PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
1546367-0	1992	Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase synthesis in Syrian hamster C100 cells by mevinolin, 25-hydroxycholesterol, and mevalonate: the role of posttranscriptional control.	25-hydroxycholesterol	115-136	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	14-61	
1546367-3	1992	The addition of 25-hydroxycholesterol to the cell culture medium resulted in a fourfold decrease in both the rate of synthesis and mRNA level for HMG-CoA reductase.	25-hydroxycholesterol	16-37	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	146-163	
1546367-6	1992	Degradation of HMG-CoA reductase was rapid in the presence (t1/2 = 1.34 h) or absence (t1/2 = 1.17 h) of mevinolin and was not changed significantly by adding either 25-hydroxycholesterol, alone (t1/2 = 1.30 h) or both 25-hydroxycholesterol and mevalonate (t1/2 = 1.30 h) to mevinolin-treated cells.	25-hydroxycholesterol	166-187	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	15-32	
1546367-6	1992	Degradation of HMG-CoA reductase was rapid in the presence (t1/2 = 1.34 h) or absence (t1/2 = 1.17 h) of mevinolin and was not changed significantly by adding either 25-hydroxycholesterol, alone (t1/2 = 1.30 h) or both 25-hydroxycholesterol and mevalonate (t1/2 = 1.30 h) to mevinolin-treated cells.	25-hydroxycholesterol	219-240	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	15-32	
1546367-7	1992	This study demonstrates that mevalonate and 25-hydroxycholesterol act synergistically in the presence of mevinolin to achieve a greater degree of suppression in the rate of HMG-CoA reductase synthesis than can be accounted for by their individual effects on HMG-CoA reductase mRNA.	25-hydroxycholesterol	44-65	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	173-190	
1546367-7	1992	This study demonstrates that mevalonate and 25-hydroxycholesterol act synergistically in the presence of mevinolin to achieve a greater degree of suppression in the rate of HMG-CoA reductase synthesis than can be accounted for by their individual effects on HMG-CoA reductase mRNA.	25-hydroxycholesterol	44-65	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	258-275