PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29689289-1 2018 Dihydroxycholesterols such as 7alpha,25-dihydroxysterols (7alpha,25-OHC) and 7alpha,27-OHC are generated from cholesterol by the enzymes CH25H, CYP7B1 and CYP27A1 in steady state but also in the context of inflammation. 25-hydroxycholesterol 65-71 cytochrome P450 family 27 subfamily A member 1 Homo sapiens 155-162 30710743-2 2019 The mitochondrial CYP27A1 initiated pathway of cholesterol metabolism (acidic pathway) is known to synthesize two well-described vital regulators of cholesterol/lipid homeostasis, (25R)-26-hydroxycholesterol (26HC) and 25-hydroxycholesterol (25HC). 25-hydroxycholesterol 219-240 cytochrome P450 family 27 subfamily A member 1 Homo sapiens 18-25 26230055-2 2015 Addition of cholesterol 25-hydroperoxide to the enzymes CYP27A1 and CYP11A1 induced well-defined spectral changes while generating 25-hydroxycholesterol as the major product. 25-hydroxycholesterol 131-152 cytochrome P450 family 27 subfamily A member 1 Homo sapiens 56-63 26230055-6 2015 CYP27A1 was shown to mediate the reduction of cholesterol 25-hydroperoxide to 25-hydroxycholesterol, a role of potential significance for cholesterol-rich tissues with high oxidative stress. 25-hydroxycholesterol 78-99 cytochrome P450 family 27 subfamily A member 1 Homo sapiens 0-7 26230055-7 2015 CYP27A1 may participate in the removal of harmful autoxidation products in these tissues, while providing a complementary source of 25-hydroxycholesterol, a modulator of immune cell function and mediator of viral cell entry. 25-hydroxycholesterol 132-153 cytochrome P450 family 27 subfamily A member 1 Homo sapiens 0-7