PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28161398-6	2017	Intraperitoneal injection of 25-hydroxycholesterol (25-OHC), the product of Ch25h, resulted in muscle loss in C57BL/6 mice, accompanied by increased expression of atrogin-1, MuRF1 and suppression of IGF-1/Akt signaling pathway.	25-hydroxycholesterol	29-50	thymoma viral proto-oncogene 1	Mus musculus	205-208	
30091835-10	2018	In summary, this study demonstrates that 25HC could inhibit the overwhelming inflammatory response through MD-2 interaction, which suppresses Akt/NF-kappaB signalling pathway.	25-hydroxycholesterol	41-45	thymoma viral proto-oncogene 1	Mus musculus	142-145	
19464253-0	2009	Stimulation of Akt poly-ubiquitination and proteasomal degradation in P388D1 cells by 7-ketocholesterol and 25-hydroxycholesterol.	25-hydroxycholesterol	108-129	thymoma viral proto-oncogene 1	Mus musculus	15-18	
19464253-2	2009	Previously we observed enhanced degradation of Akt in P388D1 moncocyte/macrophages following treatment with 25-hydroxycholesterol (25-OH) or 7-ketocholesterol (7-KC).	25-hydroxycholesterol	108-129	thymoma viral proto-oncogene 1	Mus musculus	47-50	
19464253-2	2009	Previously we observed enhanced degradation of Akt in P388D1 moncocyte/macrophages following treatment with 25-hydroxycholesterol (25-OH) or 7-ketocholesterol (7-KC).	25-hydroxycholesterol	131-136	thymoma viral proto-oncogene 1	Mus musculus	47-50	
19464253-4	2009	We show that treatment with 25-OH or 7-KC results in the accumulation of poly-ubiquitinated Akt, an effect that is enhanced by co-treatment with the proteasome inhibitor MG-132.	25-hydroxycholesterol	28-33	thymoma viral proto-oncogene 1	Mus musculus	92-95	
19464253-5	2009	Modification of Akt by the addition of a Gly-Ala repeat (GAr), a domain known to block ubiquitin-dependent targeting of proteins to the proteasome, resulted in a chimeric protein that is resistant to turn-over induced by 25-OH or 7-KC and provides protection from apoptosis induced by these oxysterols.	25-hydroxycholesterol	221-226	thymoma viral proto-oncogene 1	Mus musculus	16-19	
14559920-4	2004	In this study, we demonstrate that, in the murine macrophage-like cell line P388D1, oxysterols (25-hydroxycholesterol and 7-ketocholesterol) induced the degradation of the prosurvival protein kinase AKT (protein kinase B).	25-hydroxycholesterol	96-117	thymoma viral proto-oncogene 1	Mus musculus	199-202