PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
7713903-4	1995	In the presence of BFA (1 microgram/ml), 25-hydroxycholesterol-mediated suppression of mRNAs for HMG-CoA reductase, the low density lipoprotein receptor, and farnesyl-diphosphate synthase was almost completely blocked.	25-hydroxycholesterol	41-62	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Cricetulus griseus	97-114	
7713903-8	1995	Monensin was also found to block the effects of 25-hydroxycholesterol on suppression of HMG-CoA reductase.	25-hydroxycholesterol	48-69	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Cricetulus griseus	88-105	
2117604-9	1990	25-Hydroxycholesterol is a poor regulator of the synthesis and degradation of the rate-limiting enzyme, 3-hydroxy-3-methylglutaryl-coenzyme A reductase in crB in comparison to the wild-type Chinese hamster ovary K1 cells.	25-hydroxycholesterol	0-21	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Cricetulus griseus	104-151	
7126620-1	1982	The activity of the rate-limiting enzyme of the cholesterol biosynthetic pathway, 3-hydroxy-3-methylglutaryl coenzyme A reductase in Chinese hamster ovary (CHO) cells decreased more rapidly in cells treated with 25-hydroxycholesterol alone (t 1/2 = 1.5 h) than in those incubated with cycloheximide alone (t 1/2 = 5 h).	25-hydroxycholesterol	212-233	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Cricetulus griseus	82-129	
2917146-0	1989	Treatment of CHO-K1 cells with 25-hydroxycholesterol produces a more rapid loss of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity than can be accounted for by enzyme turnover.	25-hydroxycholesterol	31-52	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Cricetulus griseus	83-130	
7240196-0	1981	Evidence indicating that inactivation of 3-hydroxy-3-methylglutaryl coenzyme A reductase by low density lipoprotein or by 25-hydroxycholesterol requires mediator protein(s) with rapid turnover rate.	25-hydroxycholesterol	122-143	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Cricetulus griseus	41-88