PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17008555-3 2007 We demonstrated that human NPC1L1 mRNA expression was significantly decreased by 25-hydroxycholesterol but increased in response to cellular cholesterol depletion achieved by incubation with Mevinolin (an inhibitor of 3-hydroxy-3-methylglutaryl-CoA reductase) in human intestinal Caco-2 cells. 25-hydroxycholesterol 81-102 NPC1 like intracellular cholesterol transporter 1 Homo sapiens 27-33 17008555-4 2007 We also showed that a -1741/+56 fragment of the NPC1L1 gene demonstrated high promoter activity in Caco-2 cells that was reduced by 25-hydroxycholesterol and stimulated by cholesterol depletion. 25-hydroxycholesterol 132-153 NPC1 like intracellular cholesterol transporter 1 Homo sapiens 48-54