PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32859970-1 2020 Cholesterol 25-hydroxylase (CH25H) encodes the enzyme that converts cholesterol to 25-hydroxycholesterol (25-HC). 25-hydroxycholesterol 83-104 cholesterol 25-hydroxylase Mus musculus 0-26 32859970-1 2020 Cholesterol 25-hydroxylase (CH25H) encodes the enzyme that converts cholesterol to 25-hydroxycholesterol (25-HC). 25-hydroxycholesterol 83-104 cholesterol 25-hydroxylase Mus musculus 28-33 32859970-1 2020 Cholesterol 25-hydroxylase (CH25H) encodes the enzyme that converts cholesterol to 25-hydroxycholesterol (25-HC). 25-hydroxycholesterol 106-111 cholesterol 25-hydroxylase Mus musculus 0-26 32859970-1 2020 Cholesterol 25-hydroxylase (CH25H) encodes the enzyme that converts cholesterol to 25-hydroxycholesterol (25-HC). 25-hydroxycholesterol 106-111 cholesterol 25-hydroxylase Mus musculus 28-33 32859970-5 2020 The function of CH25H was investigated using loss-of-function and gain-of-function such as Ch25h-deficient mice, supplementation with exogenous 25-HC and treatment of 25-HC into Caco2 and HCT116 colonic epithelial cells. 25-hydroxycholesterol 144-149 cholesterol 25-hydroxylase Mus musculus 16-21 32343675-2 2020 AM expression of cholesterol-25-hydroxylase (CH25H), the primary biosynthetic enzyme for 25-hydroxycholesterol (25HC), far exceeds that of macrophages in other tissues, but no role for CH25H has been defined in lung biology. 25-hydroxycholesterol 89-110 cholesterol 25-hydroxylase Mus musculus 17-43 32552741-4 2020 Cholesterol 25-hydroxylase (CH25H), the enzyme responsible for 25-HC production, has also been found to be one of the disease-associated microglial (DAM) genes that are upregulated in the brain of AD and AD transgenic mouse models. 25-hydroxycholesterol 63-68 cholesterol 25-hydroxylase Mus musculus 0-26 32552741-4 2020 Cholesterol 25-hydroxylase (CH25H), the enzyme responsible for 25-HC production, has also been found to be one of the disease-associated microglial (DAM) genes that are upregulated in the brain of AD and AD transgenic mouse models. 25-hydroxycholesterol 63-68 cholesterol 25-hydroxylase Mus musculus 28-33 32343675-2 2020 AM expression of cholesterol-25-hydroxylase (CH25H), the primary biosynthetic enzyme for 25-hydroxycholesterol (25HC), far exceeds that of macrophages in other tissues, but no role for CH25H has been defined in lung biology. 25-hydroxycholesterol 89-110 cholesterol 25-hydroxylase Mus musculus 45-50 32343675-3 2020 As 25HC is an agonist for the anti-inflammatory nuclear receptor, Liver X Receptor (LXR), we speculated that CH25H might regulate inflammatory homeostasis in the lung. 25-hydroxycholesterol 3-7 cholesterol 25-hydroxylase Mus musculus 109-114 32343675-5 2020 Ch25h-/- mice fail to induce 25HC and LXR target genes in the lung after LPS inhalation and exhibit delayed resolution of airway neutrophilia which can be rescued by systemic treatment with either 25HC or synthetic LXR agonists. 25-hydroxycholesterol 29-33 cholesterol 25-hydroxylase Mus musculus 0-5 28592401-2 2017 WD also increased the expression of cholesterol 25-hydroxylase (CH25H) as measured by RT-qPCR (P < 0.0001), IHC (P = 0.0019), and ELISA (P < 0.0001), resulting in increased levels of 25-hydroxycholesterol (25-OHC) in jejunum as determined by LC-MS/MS (P < 0.0001). 25-hydroxycholesterol 189-210 cholesterol 25-hydroxylase Mus musculus 36-62 28592401-2 2017 WD also increased the expression of cholesterol 25-hydroxylase (CH25H) as measured by RT-qPCR (P < 0.0001), IHC (P = 0.0019), and ELISA (P < 0.0001), resulting in increased levels of 25-hydroxycholesterol (25-OHC) in jejunum as determined by LC-MS/MS (P < 0.0001). 25-hydroxycholesterol 189-210 cholesterol 25-hydroxylase Mus musculus 64-69 28592401-2 2017 WD also increased the expression of cholesterol 25-hydroxylase (CH25H) as measured by RT-qPCR (P < 0.0001), IHC (P = 0.0019), and ELISA (P < 0.0001), resulting in increased levels of 25-hydroxycholesterol (25-OHC) in jejunum as determined by LC-MS/MS (P < 0.0001). 25-hydroxycholesterol 212-218 cholesterol 25-hydroxylase Mus musculus 36-62 28592401-2 2017 WD also increased the expression of cholesterol 25-hydroxylase (CH25H) as measured by RT-qPCR (P < 0.0001), IHC (P = 0.0019), and ELISA (P < 0.0001), resulting in increased levels of 25-hydroxycholesterol (25-OHC) in jejunum as determined by LC-MS/MS (P < 0.0001). 25-hydroxycholesterol 212-218 cholesterol 25-hydroxylase Mus musculus 64-69 23239817-7 2013 Notably, we identified decreased expression of the mRNA encoding cholesterol 25-hydroxylase (Ch25h), an enzyme that converts cholesterol to 25-hydroxycholesterol (25HC), an oxysterol with emerging roles in immunity. 25-hydroxycholesterol 140-161 cholesterol 25-hydroxylase Mus musculus 65-91 28161398-6 2017 Intraperitoneal injection of 25-hydroxycholesterol (25-OHC), the product of Ch25h, resulted in muscle loss in C57BL/6 mice, accompanied by increased expression of atrogin-1, MuRF1 and suppression of IGF-1/Akt signaling pathway. 25-hydroxycholesterol 29-50 cholesterol 25-hydroxylase Mus musculus 76-81 22732193-5 2013 The dioxygenase enzyme cholesterol 25-hydroxylase has been shown to generate 25-hydroxycholesterol, but in cholesterol 25-hydroxylase knockout mice there are still significant levels of 25-hydroxycholesterol in several tissues. 25-hydroxycholesterol 77-98 cholesterol 25-hydroxylase Mus musculus 23-49 22732193-5 2013 The dioxygenase enzyme cholesterol 25-hydroxylase has been shown to generate 25-hydroxycholesterol, but in cholesterol 25-hydroxylase knockout mice there are still significant levels of 25-hydroxycholesterol in several tissues. 25-hydroxycholesterol 186-207 cholesterol 25-hydroxylase Mus musculus 23-49 22732193-5 2013 The dioxygenase enzyme cholesterol 25-hydroxylase has been shown to generate 25-hydroxycholesterol, but in cholesterol 25-hydroxylase knockout mice there are still significant levels of 25-hydroxycholesterol in several tissues. 25-hydroxycholesterol 186-207 cholesterol 25-hydroxylase Mus musculus 107-133 23273844-3 2013 CH25H converts cholesterol to a soluble antiviral factor, 25-hydroxycholesterol (25HC). 25-hydroxycholesterol 81-85 cholesterol 25-hydroxylase Mus musculus 0-5 23273844-0 2013 Interferon-inducible cholesterol-25-hydroxylase broadly inhibits viral entry by production of 25-hydroxycholesterol. 25-hydroxycholesterol 94-115 cholesterol 25-hydroxylase Mus musculus 21-47 23273844-3 2013 CH25H converts cholesterol to a soluble antiviral factor, 25-hydroxycholesterol (25HC). 25-hydroxycholesterol 58-79 cholesterol 25-hydroxylase Mus musculus 0-5 23239817-7 2013 Notably, we identified decreased expression of the mRNA encoding cholesterol 25-hydroxylase (Ch25h), an enzyme that converts cholesterol to 25-hydroxycholesterol (25HC), an oxysterol with emerging roles in immunity. 25-hydroxycholesterol 140-161 cholesterol 25-hydroxylase Mus musculus 93-98 34725187-11 2021 Effects of LPS on both synaptic plasticity and one-trial inhibitory avoidance learning are eliminated in mice deficient in Ch25h, the primary enzyme responsible for endogenous 25HC synthesis. 25-hydroxycholesterol 176-180 cholesterol 25-hydroxylase Mus musculus 123-128 34090999-7 2021 Use of the anti-hypertensive drug, reserpine, mimicked the effects of the CH25H product 25-hydroxycholesterol to suppress TEV uptake and TEV-mediated tumor growth, pre-metastatic niche formation, and lung metastasis. 25-hydroxycholesterol 88-109 cholesterol 25-hydroxylase Mus musculus 74-79 35462473-2 2022 Cholesterol 25-hydroxylase (Ch25h) and its product, 25-hydroxycholesterol (25-HC), play important roles in cholesterol homeostasis and inflammation, but whether Ch25h and 25-HC are involved in NAFLD remains uncertain. 25-hydroxycholesterol 52-73 cholesterol 25-hydroxylase Mus musculus 0-26 35462473-2 2022 Cholesterol 25-hydroxylase (Ch25h) and its product, 25-hydroxycholesterol (25-HC), play important roles in cholesterol homeostasis and inflammation, but whether Ch25h and 25-HC are involved in NAFLD remains uncertain. 25-hydroxycholesterol 52-73 cholesterol 25-hydroxylase Mus musculus 28-33 35462473-2 2022 Cholesterol 25-hydroxylase (Ch25h) and its product, 25-hydroxycholesterol (25-HC), play important roles in cholesterol homeostasis and inflammation, but whether Ch25h and 25-HC are involved in NAFLD remains uncertain. 25-hydroxycholesterol 75-80 cholesterol 25-hydroxylase Mus musculus 0-26 35462473-2 2022 Cholesterol 25-hydroxylase (Ch25h) and its product, 25-hydroxycholesterol (25-HC), play important roles in cholesterol homeostasis and inflammation, but whether Ch25h and 25-HC are involved in NAFLD remains uncertain. 25-hydroxycholesterol 75-80 cholesterol 25-hydroxylase Mus musculus 28-33 34990887-1 2022 BACKGROUND & AIMS: Cholesterol 25-hydroxylase (Ch25h), converting cholesterol to 25-hydroxycholesterol (25-HC), is critical in modulating cellular lipid metabolism and anti-inflammatory and antiviral activities. 25-hydroxycholesterol 81-102 cholesterol 25-hydroxylase Mus musculus 19-45 34990887-1 2022 BACKGROUND & AIMS: Cholesterol 25-hydroxylase (Ch25h), converting cholesterol to 25-hydroxycholesterol (25-HC), is critical in modulating cellular lipid metabolism and anti-inflammatory and antiviral activities. 25-hydroxycholesterol 81-102 cholesterol 25-hydroxylase Mus musculus 47-52 34990887-1 2022 BACKGROUND & AIMS: Cholesterol 25-hydroxylase (Ch25h), converting cholesterol to 25-hydroxycholesterol (25-HC), is critical in modulating cellular lipid metabolism and anti-inflammatory and antiviral activities. 25-hydroxycholesterol 104-109 cholesterol 25-hydroxylase Mus musculus 19-45 34990887-1 2022 BACKGROUND & AIMS: Cholesterol 25-hydroxylase (Ch25h), converting cholesterol to 25-hydroxycholesterol (25-HC), is critical in modulating cellular lipid metabolism and anti-inflammatory and antiviral activities. 25-hydroxycholesterol 104-109 cholesterol 25-hydroxylase Mus musculus 47-52