PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34253143-3	2021	To understand the co-evolutionary molecular mechanisms of resistance in the HIV-1 PR and Gag, we performed 100 ns molecular dynamic simulations on multidrug resistant PR"s when bound to LPV, DRV or a mutated A431V NC p1 Gag cleavage site (CS).	Lopinavir	186-189	transmembrane protein 37	Homo sapiens	82-84	
34397829-13	2021	CONCLUSION: Limited evidence suggests that lopinavir, ritonavir, atazanavir, and saquinavir could cause PR prolongation, QRS widening, and QT prolongation.	Lopinavir	43-52	transmembrane protein 37	Homo sapiens	104-106	
34253143-3	2021	To understand the co-evolutionary molecular mechanisms of resistance in the HIV-1 PR and Gag, we performed 100 ns molecular dynamic simulations on multidrug resistant PR"s when bound to LPV, DRV or a mutated A431V NC p1 Gag cleavage site (CS).	Lopinavir	186-189	transmembrane protein 37	Homo sapiens	167-169	
34253143-4	2021	Here we showed that distinct changes in PR"s active site, flap and elbow regions due to several PR resistance mutations (L10F, M46I, I54V, L76V, V82A) were found to alter LPV and DRV drug binding.	Lopinavir	171-174	transmembrane protein 37	Homo sapiens	40-42	
34253143-4	2021	Here we showed that distinct changes in PR"s active site, flap and elbow regions due to several PR resistance mutations (L10F, M46I, I54V, L76V, V82A) were found to alter LPV and DRV drug binding.	Lopinavir	171-174	transmembrane protein 37	Homo sapiens	96-98