PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22198116-0 2012 Anthraquinone antitumour agents, doxorubicin, pirarubicin and benzoperimidine BP1, trigger caspase-3/caspase-8-dependent apoptosis of leukaemia sensitive HL60 and resistant HL60/VINC and HL60/DOX cells. Anthraquinones 0-13 nuclear paraspeckle assembly transcript 1 Homo sapiens 178-182 22198116-3 2012 Interestingly, it was seen that HL60/VINC cells were more susceptible to undergo caspase-3/caspase-8-dependent apoptosis induced by the studied anthraquinone compounds compared with HL60 and HL60/DOX cells. Anthraquinones 144-157 nuclear paraspeckle assembly transcript 1 Homo sapiens 37-41 22205152-5 2012 In the second part of the work, the ability of antitumour anthraquinone derivatives and analogues to inhibit the growth of the human promyelocytic, sensitive leukaemia HL60 cell line as well as its MDR sublines exhibiting two different phenotypes of MDR related to the overexpression of P-glycoprotein (HL60/VINC) or MRP1 (HL60/DOX) was studied in the presence of exogenously added CPR. Anthraquinones 58-71 nuclear paraspeckle assembly transcript 1 Homo sapiens 308-312