PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24685584-0	2014	Interaction of five anthraquinones from rhubarb with human organic anion transporter 1 (SLC22A6) and 3 (SLC22A8) and drug-drug interaction in rats.	Anthraquinones	20-34	solute carrier family 22 member 8	Homo sapiens	104-111	
26133709-0	2015	Time-Dependent Inhibition of hOAT1 and hOAT3 by Anthraquinones.	Anthraquinones	48-62	solute carrier family 22 member 8	Homo sapiens	39-44	
26133709-1	2015	We previously showed that anthraquinones (including rhein, emodin, aloe-emodin, chrysophanol and physcion) were inhibitors of human organic anion transporter 1 (hOAT1) and hOAT3, causing transporter-mediated drug-drug interactions in rats.	Anthraquinones	26-40	solute carrier family 22 member 8	Homo sapiens	172-177	
26133709-2	2015	In this study, the time-dependent inhibition (TDI) of hOAT1 and hOAT3 by anthraquinones was investigated.	Anthraquinones	73-87	solute carrier family 22 member 8	Homo sapiens	64-69	
26133709-7	2015	In conclusion, our results suggest that some anthraquinones contribute to the TDI of hOAT1 and hOAT3.	Anthraquinones	45-59	solute carrier family 22 member 8	Homo sapiens	95-100	
26133709-8	2015	An inhibition study without the preincubation procedure may underestimate the inhibitory potential of anthraquinones against hOAT1 and hOAT3.	Anthraquinones	102-116	solute carrier family 22 member 8	Homo sapiens	135-140	
24685584-3	2014	MATERIALS AND METHODS: Here we studied the interaction of five anthraquinone derivatives with human renal organic anion transporter 1 (hOAT1) and hOAT3 stably expressed in cells, and interaction of rhein or rhubarb extract (RE) with furosemide (FS, substrate of OATs) in rats.	Anthraquinones	63-76	solute carrier family 22 member 8	Homo sapiens	146-151	
24685584-9	2014	CONCLUSIONS: These findings suggested that five anthraquinones inhibited hOAT1 and hOAT3, but these compounds were not transported by hOAT1 or hOAT3.	Anthraquinones	48-62	solute carrier family 22 member 8	Homo sapiens	83-88