PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22923786-3 2012 Methyl-beta-cyclodextrin (MBCD) has been shown to reduce lysosomal cholesterol accumulation in skin fibroblasts derived from patients with Niemann Pick type C disease and in the NPC1-/- mouse model. methyl-beta-cyclodextrin 0-24 NPC intracellular cholesterol transporter 1 Homo sapiens 178-182 28613987-3 2017 We found that methyl-beta-cyclodextrin (MbetaCD), a potent analog of HPbetaCD, restored impaired macroautophagy/autophagy flux in Niemann-Pick disease, type C1 (NPC1) cells. methyl-beta-cyclodextrin 14-38 NPC intracellular cholesterol transporter 1 Homo sapiens 130-159 28613987-3 2017 We found that methyl-beta-cyclodextrin (MbetaCD), a potent analog of HPbetaCD, restored impaired macroautophagy/autophagy flux in Niemann-Pick disease, type C1 (NPC1) cells. methyl-beta-cyclodextrin 14-38 NPC intracellular cholesterol transporter 1 Homo sapiens 161-165 28613987-3 2017 We found that methyl-beta-cyclodextrin (MbetaCD), a potent analog of HPbetaCD, restored impaired macroautophagy/autophagy flux in Niemann-Pick disease, type C1 (NPC1) cells. methyl-beta-cyclodextrin 40-47 NPC intracellular cholesterol transporter 1 Homo sapiens 130-159 28613987-3 2017 We found that methyl-beta-cyclodextrin (MbetaCD), a potent analog of HPbetaCD, restored impaired macroautophagy/autophagy flux in Niemann-Pick disease, type C1 (NPC1) cells. methyl-beta-cyclodextrin 40-47 NPC intracellular cholesterol transporter 1 Homo sapiens 161-165 28613987-5 2017 Knockdown of PRKAB1 or PRKAB2 (encoding the AMPK beta1 or beta2 subunit) expression and an AMPK inhibitor abolished MbetaCD-mediated reduction of cholesterol storage in NPC1 cells. methyl-beta-cyclodextrin 116-123 NPC intracellular cholesterol transporter 1 Homo sapiens 169-173 28631941-1 2017 Methyl-beta-cyclodextrin (MbetaCD) reduces lysosomal cholesterol accumulation in Niemann-Pick disease type C1 (NPC1) patient fibroblasts. methyl-beta-cyclodextrin 0-24 NPC intracellular cholesterol transporter 1 Homo sapiens 81-109 28631941-1 2017 Methyl-beta-cyclodextrin (MbetaCD) reduces lysosomal cholesterol accumulation in Niemann-Pick disease type C1 (NPC1) patient fibroblasts. methyl-beta-cyclodextrin 0-24 NPC intracellular cholesterol transporter 1 Homo sapiens 111-115 28631941-1 2017 Methyl-beta-cyclodextrin (MbetaCD) reduces lysosomal cholesterol accumulation in Niemann-Pick disease type C1 (NPC1) patient fibroblasts. methyl-beta-cyclodextrin 26-33 NPC intracellular cholesterol transporter 1 Homo sapiens 81-109 28631941-1 2017 Methyl-beta-cyclodextrin (MbetaCD) reduces lysosomal cholesterol accumulation in Niemann-Pick disease type C1 (NPC1) patient fibroblasts. methyl-beta-cyclodextrin 26-33 NPC intracellular cholesterol transporter 1 Homo sapiens 111-115 28631941-5 2017 Furthermore, a proteomic analysis showed the differences of these three MbetaCD preparations on amelioration of dysregulated protein expression levels in NPC1 cells. methyl-beta-cyclodextrin 72-79 NPC intracellular cholesterol transporter 1 Homo sapiens 154-158