PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22923786-3	2012	Methyl-beta-cyclodextrin (MBCD) has been shown to reduce lysosomal cholesterol accumulation in skin fibroblasts derived from patients with Niemann Pick type C disease and in the NPC1-/- mouse model.	methyl-beta-cyclodextrin	0-24	NPC intracellular cholesterol transporter 1	Homo sapiens	178-182	
28613987-3	2017	We found that methyl-beta-cyclodextrin (MbetaCD), a potent analog of HPbetaCD, restored impaired macroautophagy/autophagy flux in Niemann-Pick disease, type C1 (NPC1) cells.	methyl-beta-cyclodextrin	14-38	NPC intracellular cholesterol transporter 1	Homo sapiens	130-159	
28613987-3	2017	We found that methyl-beta-cyclodextrin (MbetaCD), a potent analog of HPbetaCD, restored impaired macroautophagy/autophagy flux in Niemann-Pick disease, type C1 (NPC1) cells.	methyl-beta-cyclodextrin	14-38	NPC intracellular cholesterol transporter 1	Homo sapiens	161-165	
28613987-3	2017	We found that methyl-beta-cyclodextrin (MbetaCD), a potent analog of HPbetaCD, restored impaired macroautophagy/autophagy flux in Niemann-Pick disease, type C1 (NPC1) cells.	methyl-beta-cyclodextrin	40-47	NPC intracellular cholesterol transporter 1	Homo sapiens	130-159	
28613987-3	2017	We found that methyl-beta-cyclodextrin (MbetaCD), a potent analog of HPbetaCD, restored impaired macroautophagy/autophagy flux in Niemann-Pick disease, type C1 (NPC1) cells.	methyl-beta-cyclodextrin	40-47	NPC intracellular cholesterol transporter 1	Homo sapiens	161-165	
28613987-5	2017	Knockdown of PRKAB1 or PRKAB2 (encoding the AMPK beta1 or beta2 subunit) expression and an AMPK inhibitor abolished MbetaCD-mediated reduction of cholesterol storage in NPC1 cells.	methyl-beta-cyclodextrin	116-123	NPC intracellular cholesterol transporter 1	Homo sapiens	169-173	
28631941-1	2017	Methyl-beta-cyclodextrin (MbetaCD) reduces lysosomal cholesterol accumulation in Niemann-Pick disease type C1 (NPC1) patient fibroblasts.	methyl-beta-cyclodextrin	0-24	NPC intracellular cholesterol transporter 1	Homo sapiens	81-109	
28631941-1	2017	Methyl-beta-cyclodextrin (MbetaCD) reduces lysosomal cholesterol accumulation in Niemann-Pick disease type C1 (NPC1) patient fibroblasts.	methyl-beta-cyclodextrin	0-24	NPC intracellular cholesterol transporter 1	Homo sapiens	111-115	
28631941-1	2017	Methyl-beta-cyclodextrin (MbetaCD) reduces lysosomal cholesterol accumulation in Niemann-Pick disease type C1 (NPC1) patient fibroblasts.	methyl-beta-cyclodextrin	26-33	NPC intracellular cholesterol transporter 1	Homo sapiens	81-109	
28631941-1	2017	Methyl-beta-cyclodextrin (MbetaCD) reduces lysosomal cholesterol accumulation in Niemann-Pick disease type C1 (NPC1) patient fibroblasts.	methyl-beta-cyclodextrin	26-33	NPC intracellular cholesterol transporter 1	Homo sapiens	111-115	
28631941-5	2017	Furthermore, a proteomic analysis showed the differences of these three MbetaCD preparations on amelioration of dysregulated protein expression levels in NPC1 cells.	methyl-beta-cyclodextrin	72-79	NPC intracellular cholesterol transporter 1	Homo sapiens	154-158