PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20501660-0	2010	Methyl-beta-cyclodextrin suppresses hyaluronan synthesis by down-regulation of hyaluronan synthase 2 through inhibition of Akt.	methyl-beta-cyclodextrin	0-24	hyaluronan synthase 2	Homo sapiens	79-100	
20501660-6	2010	Instead, MbetaCD specifically down-regulated the expression of HAS2 but not HAS1 or HAS3.	methyl-beta-cyclodextrin	9-16	hyaluronan synthase 2	Homo sapiens	63-67	
20501660-8	2010	Inhibitors of this pathway suppressed hyaluronan synthesis and HAS2 expression in MCF-7 cells, suggesting that the reduced hyaluronan synthesis by MbetaCD is due to down-regulation of HAS2, mediated by the phosphoinositide 3-kinase-Akt-mTOR-p70S6K pathway.	methyl-beta-cyclodextrin	147-154	hyaluronan synthase 2	Homo sapiens	184-188