PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32905663-7	2021	Bufalin inhibits the mammalian target of rapamycin (mTOR) activation and subsequently decreases hypoxia-induced factor 1 alpha (HIF-1alpha) level.	bufalin	0-7	hypoxia inducible factor 1 subunit alpha	Homo sapiens	128-138	
32905663-8	2021	Over-expression of HIF-1alpha could abolish the pro-apoptotic and anti-migration activity of bufalin in cell culture.	bufalin	93-100	hypoxia inducible factor 1 subunit alpha	Homo sapiens	19-29	
32905663-10	2021	Bufalin was a potent inhibitor of cell growth and migration in ovarian cancer cells through suppression of mTOR activation and HIF-1alpha induction.	bufalin	0-7	hypoxia inducible factor 1 subunit alpha	Homo sapiens	127-137	
32362830-0	2020	Silencing c-Myc Enhances the Antitumor Activity of Bufalin by Suppressing the HIF-1alpha/SDF-1/CXCR4 Pathway in Pancreatic Cancer Cells.	bufalin	51-58	hypoxia inducible factor 1 subunit alpha	Homo sapiens	78-88	
32362830-17	2020	The in vivo studies verified the results that c-Myc enhances the effect of bufalin through regulation of the HIF-1alpha/SDF-1/CXCR4 pathway.	bufalin	75-82	hypoxia inducible factor 1 subunit alpha	Homo sapiens	109-119	
32362830-18	2020	Conclusions: Downregulation of c-Myc enhanced the antitumor activity of bufalin in pancreatic cancer cells by suppressing the HIF-1alpha/SDF-1/CXCR4 pathway.	bufalin	72-79	hypoxia inducible factor 1 subunit alpha	Homo sapiens	126-136	
30128000-3	2018	In the present study, it was demonstrated that bufalin inhibited cell proliferation, blocked the cell cycle in the G2/M phase, and reduced the metastasis of human RCC ACHN cells via the upregulation of p21waf/cip1 and E-cadherin and the downregulation of cyclin dependent kinase 1, cyclin B1, N-cadherin, and hypoxia-inducible factor-1alpha (HIF-1alpha).	bufalin	47-54	hypoxia inducible factor 1 subunit alpha	Homo sapiens	309-340	
30128000-3	2018	In the present study, it was demonstrated that bufalin inhibited cell proliferation, blocked the cell cycle in the G2/M phase, and reduced the metastasis of human RCC ACHN cells via the upregulation of p21waf/cip1 and E-cadherin and the downregulation of cyclin dependent kinase 1, cyclin B1, N-cadherin, and hypoxia-inducible factor-1alpha (HIF-1alpha).	bufalin	47-54	hypoxia inducible factor 1 subunit alpha	Homo sapiens	342-352	
29616114-9	2018	Furthermore, treatment with bufalin abolished HIF-1alpha expression under hypoxia, suggesting that bufalin exerts cytotoxicity under hypoxia by regulating HIF-1alpha.	bufalin	28-35	hypoxia inducible factor 1 subunit alpha	Homo sapiens	46-56	
29616114-9	2018	Furthermore, treatment with bufalin abolished HIF-1alpha expression under hypoxia, suggesting that bufalin exerts cytotoxicity under hypoxia by regulating HIF-1alpha.	bufalin	28-35	hypoxia inducible factor 1 subunit alpha	Homo sapiens	155-165	
29616114-9	2018	Furthermore, treatment with bufalin abolished HIF-1alpha expression under hypoxia, suggesting that bufalin exerts cytotoxicity under hypoxia by regulating HIF-1alpha.	bufalin	99-106	hypoxia inducible factor 1 subunit alpha	Homo sapiens	46-56	
29616114-9	2018	Furthermore, treatment with bufalin abolished HIF-1alpha expression under hypoxia, suggesting that bufalin exerts cytotoxicity under hypoxia by regulating HIF-1alpha.	bufalin	99-106	hypoxia inducible factor 1 subunit alpha	Homo sapiens	155-165	
29616114-10	2018	These results indicate that bufalin induces apoptosis in MM cells through DSB under hypoxic conditions by inhibiting HIF-1alpha, suggesting that bufalin could be useful for eradication of drug-resistant MM cells in the hypoxic microenvironment.	bufalin	28-35	hypoxia inducible factor 1 subunit alpha	Homo sapiens	117-127	
29616114-10	2018	These results indicate that bufalin induces apoptosis in MM cells through DSB under hypoxic conditions by inhibiting HIF-1alpha, suggesting that bufalin could be useful for eradication of drug-resistant MM cells in the hypoxic microenvironment.	bufalin	145-152	hypoxia inducible factor 1 subunit alpha	Homo sapiens	117-127	
26958938-0	2016	Bufalin suppresses hepatocellular carcinoma invasion and metastasis by targeting HIF-1alpha via the PI3K/AKT/mTOR pathway.	bufalin	0-7	hypoxia inducible factor 1 subunit alpha	Homo sapiens	81-91	
26958938-9	2016	Mechanistically, our study demonstrated that hypoxia-inducible factor-1alpha (HIF-1alpha) played an important role in the antimetastatic effect of bufalin in hepatocellular carcinoma.	bufalin	147-154	hypoxia inducible factor 1 subunit alpha	Homo sapiens	45-76	
26958938-9	2016	Mechanistically, our study demonstrated that hypoxia-inducible factor-1alpha (HIF-1alpha) played an important role in the antimetastatic effect of bufalin in hepatocellular carcinoma.	bufalin	147-154	hypoxia inducible factor 1 subunit alpha	Homo sapiens	78-88