PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10822274-2 2000 In this study, we report that 100 nM calphostin C also induces translocation and integration of monomeric Bax into mitochondrial membrane, followed by cytochrome c release into cytosol and subsequent decrease of mitochondrial inner membrane potential (DeltaPsim) before activation of caspase-3. calphostin C 37-49 cytochrome c, somatic Homo sapiens 151-163 10822274-6 2000 Therefore, it would be assumed that mitochondrial release of cytochrome c results from translocation and integration of Bax and is independent of permeability transition of mitochondria and caspase activation, representing a critical step in calphostin C-induced cell death. calphostin C 242-254 cytochrome c, somatic Homo sapiens 61-73