PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
7988654-1	1994	AT1 and AT2 are the two major receptor subtypes for angiotensin II that have been pharmacologically defined by using the selective ligands losartan and PD123177, respectively.	PD 123177	152-160	angiotensin II receptor, type 2	Rattus norvegicus	8-11	
15665034-7	2005	Blockade of central AT2 receptors with PD123177 abolished the neuroprotective effects of central AT1 receptor blockade with irbesartan on infarct size and neurological outcome.	PD 123177	39-47	angiotensin II receptor, type 2	Rattus norvegicus	20-23	
9928956-4	1999	The ANG 11 effects were mediated by AT2 receptors since they were completely abolished by co-incubation with the AT2 receptor antagonist, PD123177 (10(-5) M), but not by the AT1 receptor antagonist, losartan (10(-5) M).	PD 123177	138-146	angiotensin II receptor, type 2	Rattus norvegicus	36-39	
9928956-4	1999	The ANG 11 effects were mediated by AT2 receptors since they were completely abolished by co-incubation with the AT2 receptor antagonist, PD123177 (10(-5) M), but not by the AT1 receptor antagonist, losartan (10(-5) M).	PD 123177	138-146	angiotensin II receptor, type 2	Rattus norvegicus	113-116	
10374931-3	1999	TH-142177 and losartan competed with [125I]Sar1,Ile8-AII for the binding sites in VSMC in a monophasic manner, although PD123177, a selective antagonist of angiotensin II type 2-receptor (AT2-R), had little inhibitory effect, demonstrating the predominant existence of AT1-R in rat VSMC.	PD 123177	120-128	angiotensin II receptor, type 2	Rattus norvegicus	156-186	
9473667-7	1998	All ANG II effects were abolished by the AT2 receptor antagonist PD123177 (10(-5) M) but not affected by the AT1 receptor antagonist losartan (10(-5) M).	PD 123177	65-73	angiotensin II receptor, type 2	Rattus norvegicus	41-44	
9178851-4	1997	The ANG II-induced effects were completely abolished by pretreatment with the AT2 receptor antagonist, PD123177.	PD 123177	103-111	angiotensin II receptor, type 2	Rattus norvegicus	78-81	
23007463-9	2012	The combined administration of ATII and losartan to CMS further reduced Cx43 polarisation to control levels, whilst the AT(2)-R blocker PD123177 restored polarisation.	PD 123177	136-144	angiotensin II receptor, type 2	Rattus norvegicus	120-127	
23007463-12	2012	ATII enhances total Cx43 mRNA and protein expression probably via AT(1)-R (=inhibitory effect of losartan) and reduces Cx43 polarisation presumably via AT(2)-R, since PD123177 (but not losartan) inhibited the negative effects of ATII on polarisation.	PD 123177	167-175	angiotensin II receptor, type 2	Rattus norvegicus	152-159	
7956925-6	1994	Such coculture experiments show that the promoting effect of Ang II on preadipose cell differentiation was strongly reduced by aspirin, antibodies able to neutralize PGI2, and the AT2 receptor antagonist PD123177, but not by the AT1 receptor antagonist losartan.	PD 123177	204-212	angiotensin II receptor, type 2	Rattus norvegicus	180-183	
8313407-6	1993	Competition experiments performed with the nonpeptide inhibitors losartan and PD123177 allowed identification of both AT1 and AT2 angiotensin II receptors in rat heart.	PD 123177	78-86	angiotensin II receptor, type 2	Rattus norvegicus	126-129	
8214016-4	1993	The effects were mediated by AT2 receptors (blocked by 1 microM PD-123177 but not by 1 microM losartan).	PD 123177	64-73	angiotensin II receptor, type 2	Rattus norvegicus	29-32	
1279763-4	1992	AT1 receptors, as determined in the presence of an excess concentration (10 microM) of the AT2 antagonist, PD 123177, account for 95% of total renal Ang II receptors, whereas AT2 receptors, as determined in the presence of an excess concentration (10 microM) of the AT1 antagonist, DuP 753, represent approximately 5% of total renal Ang II receptors.	PD 123177	107-116	angiotensin II receptor, type 2	Rattus norvegicus	91-94	
1423940-2	1992	Recently, two subtypes of angiotensin II receptors (AT1 and AT2) have been distinguished by using the nonpeptide antagonists losartan (previously known as DuP 753) and PD123177.	PD 123177	168-176	angiotensin II receptor, type 2	Rattus norvegicus	60-63	
1333623-5	1992	The excitation could be blocked by low doses of the AT2-antagonists PD 123177 and CGP 42112A, whereas the AT1-antagonist DuP 753 was ineffective even at high doses.	PD 123177	68-77	angiotensin II receptor, type 2	Rattus norvegicus	52-55	
8338170-6	1993	AT1 and AT2 receptor distribution was characterized by competition with the nonpeptide antagonists losartan (10 microM) and PD123177 (10 microM), respectively, and the density of receptors was quantified by counting the silver grains overlying the different layers of intestinal wall.	PD 123177	124-132	angiotensin II receptor, type 2	Rattus norvegicus	8-11	
8221742-2	1993	Recently, 2 subtypes of angiotensin II receptors (AT1 and AT2) have been distinguished using the nonpeptide antagonists losartan and PD123177.	PD 123177	133-141	angiotensin II receptor, type 2	Rattus norvegicus	58-61	
8469771-7	1993	However, dissociation occurred in the skin when AT2 sites were blocked with 10 microM PD 123177, and in liver, dissociation was not observed when AT1 sites were blocked with DuP 753.	PD 123177	86-95	angiotensin II receptor, type 2	Rattus norvegicus	48-51	
1445340-7	1992	PD123177, an AT2 selective antagonist, showed minimal inhibitory effect.	PD 123177	0-8	angiotensin II receptor, type 2	Rattus norvegicus	13-16	
1504808-5	1992	This effect is inhibited by the AT2 receptor-selective antagonists, PD123177 and PD123319 (both 100 nM), but not by the AT1-selective receptor blocker, DuP753 (Losartan; 100 nM), and so it is mediated by AT2 receptors.	PD 123177	68-76	angiotensin II receptor, type 2	Rattus norvegicus	32-35	
1406056-3	1992	In the medulla, the AT2 antagonist (PD123177, 5 microM) inhibited specific binding by 90% whereas the AT1 antagonist (DuP753, 5 microM) inhibited by only 10%.	PD 123177	36-44	angiotensin II receptor, type 2	Rattus norvegicus	20-23	
1763058-3	1991	However, binding of 125I-labeled [Sar1,Ile8]AII in the latter regions was inhibited by the AT2 receptor antagonists PD 123177 and CGP 42112A.	PD 123177	116-125	angiotensin II receptor, type 2	Rattus norvegicus	91-94	
1885777-6	1991	The highly abundant angiotensin II receptors were shown to be AT2 by the marked reduction in radioligand binding achieved with PD123177 (10(-7)M), a specific AT2 receptor antagonist, whereas DuP 753 (10(-5)M), an AT1 receptor antagonist, had little effect.	PD 123177	127-135	angiotensin II receptor, type 2	Rattus norvegicus	62-65	
1885777-6	1991	The highly abundant angiotensin II receptors were shown to be AT2 by the marked reduction in radioligand binding achieved with PD123177 (10(-7)M), a specific AT2 receptor antagonist, whereas DuP 753 (10(-5)M), an AT1 receptor antagonist, had little effect.	PD 123177	127-135	angiotensin II receptor, type 2	Rattus norvegicus	158-161