PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29295852-8	2018	We found that the protective effect of COX-2 on renal vascular function was associated with prostacyclin signaling through PPARbeta/delta (peroxisome proliferator-activated receptor-beta/delta).	Epoprostenol	92-104	peroxisome proliferator activator receptor delta	Mus musculus	123-186	
18407349-3	2008	Previous reports described that cyclooxygenase-2 (COX2) derived prostacyclin (PGI2) plays an important role via peroxisome proliferator activated receptor (PPARdelta) nuclear receptor in implantation and decidualization.	Epoprostenol	64-76	peroxisome proliferator activator receptor delta	Mus musculus	156-165	
25006409-3	2013	PPARbeta/delta is an important receptor in lipid metabolism, athletic performance, and the sensing of prostacyclin.	Epoprostenol	102-114	peroxisome proliferator activator receptor delta	Mus musculus	0-8	
24069449-9	2013	We conclude that the absence of 5-HT2B receptors leads to the overproduction of prostacyclin, inducing reduced osteoblast differentiation due to PPAR-ss/delta -dependent target regulation and defective cell-cell adhesion and matrix mineralization.	Epoprostenol	80-92	peroxisome proliferator activator receptor delta	Mus musculus	145-158	
21511721-2	2011	In particular, maternal prostacyclin (PGI(2)) is critical for embryo implantation and the action of PGI(2) is not mediated via its G-protein-coupled membrane receptor, IP, but its nuclear receptor, peroxisome-proliferator-activated receptor delta (PPARdelta).	Epoprostenol	24-36	peroxisome proliferator activator receptor delta	Mus musculus	198-246	
21511721-2	2011	In particular, maternal prostacyclin (PGI(2)) is critical for embryo implantation and the action of PGI(2) is not mediated via its G-protein-coupled membrane receptor, IP, but its nuclear receptor, peroxisome-proliferator-activated receptor delta (PPARdelta).	Epoprostenol	24-36	peroxisome proliferator activator receptor delta	Mus musculus	248-257	
25648617-0	2015	Effect of Xianziyizhen Recipe Capsule on PGI2-PPARdelta Signaling Pathway in Embryo Implantation Dysfunction Mice.	Epoprostenol	41-45	peroxisome proliferator activator receptor delta	Mus musculus	46-55	
25648617-1	2015	PROBLEM: We investigated the effect of Xianziyizhen recipe capsule (XRC), a kidney-tonifying herb, on the PGI2-PPARdelta signaling pathway at the maternal-fetal interface in embryo implantation dysfunction (EID) mice.	Epoprostenol	106-110	peroxisome proliferator activator receptor delta	Mus musculus	111-120	
25648617-7	2015	CONCLUSION: These results strongly suggested that XRC is beneficial in EID treatment and that XRC may mediate its effects through regulation of the PGI2-PPARdelta signaling pathway.	Epoprostenol	148-152	peroxisome proliferator activator receptor delta	Mus musculus	153-162	
23074280-12	2012	We identified the PPARdelta ligand PGI(2) as the most abundant AAMphi-derived eicosanoid and propose a PGI(2)-PPARdelta axis maintains AAMphi during B malayi implantation.	Epoprostenol	35-41	peroxisome proliferator activator receptor delta	Mus musculus	18-27	
15001550-1	2004	We previously showed that peroxisome proliferator-activated receptor delta (PPARdelta) is crucial for embryo implantation as a receptor for cyclooxygenase-2-derived prostacyclin in mice.	Epoprostenol	165-177	peroxisome proliferator activator receptor delta	Mus musculus	26-74	
17328923-10	2007	Our results suggest that PGI(2) may affect blastomeres number via the so called hypothesis of PPARdelta nuclear receptor in autocrine manner.	Epoprostenol	25-31	peroxisome proliferator activator receptor delta	Mus musculus	94-103	
15001550-1	2004	We previously showed that peroxisome proliferator-activated receptor delta (PPARdelta) is crucial for embryo implantation as a receptor for cyclooxygenase-2-derived prostacyclin in mice.	Epoprostenol	165-177	peroxisome proliferator activator receptor delta	Mus musculus	76-85	
10511291-3	1999	Among fatty acids, prostacyclin produced from arachidonic acid enhances the expression of both C/EBPs through cell surface IP receptor and presumably activates PPARdelta.	Epoprostenol	19-31	peroxisome proliferator activator receptor delta	Mus musculus	160-169	
11779158-3	2002	PPARdelta is activated by unsaturated fatty acids, PGI2, and by synthetic ligands.	Epoprostenol	51-55	peroxisome proliferator activator receptor delta	Mus musculus	0-9	
10385625-0	1999	Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARdelta.	Epoprostenol	26-38	peroxisome proliferator activator receptor delta	Mus musculus	85-94	
10385625-4	1999	Several lines of evidence suggest that the effects of PGI2 are mediated by its activation of the nuclear hormone receptor PPARdelta, demonstrating the first reported biologic function of this receptor signaling pathway.	Epoprostenol	54-58	peroxisome proliferator activator receptor delta	Mus musculus	122-131