PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33609687-6	2021	Interestingly, the expression of mTOR signal proteins, which were suppressed by TVX, disrupted the negative feedback of the PI3K/AKT pathway and TNFalpha rebounded p70S6K phosphorylation.	trovafloxacin	80-83	ribosomal protein S6 kinase B1	Homo sapiens	164-170	
33609687-7	2021	Co-treatment with TVX and TNFalpha inhibited protective autophagy by maintaining p70S6K activity, which enhanced TVX-induced cytotoxicity.	trovafloxacin	18-21	ribosomal protein S6 kinase B1	Homo sapiens	81-87	
33609687-8	2021	Phosphorylation of p70S6K was inhibited by siRNA knockdown and rapamycin to restore TNFalpha-inhibited autophagy, which prevented the synergistic effect on TVX-induced cytotoxicity.	trovafloxacin	156-159	ribosomal protein S6 kinase B1	Homo sapiens	19-25