PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12529972-2	2002	MATERIALS AND METHODS: To understand the mechanism of beta 2m-induced apoptosis, we added purified human beta 2m to cultures of K562 human chronic myelocytic leukemia cells, detected apoptosis by DNA fragmentation and annexin V binding assays, measured mitochondrial membrane potential (delta psi m), and used Z-VAD-fmk, a general inhibitor of caspases, inhibitors of caspases-1 and-3, as well as Western blot analysis to detect activated caspases.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	310-319	beta-2-microglobulin	Homo sapiens	54-61	
12529972-4	2002	Treatment with the general caspase inhibitor Z-VAD-fmk, as well as the caspase-1 inhibitor YVAD-CHO, significantly blocked beta 2m-induced apoptosis.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	45-54	beta-2-microglobulin	Homo sapiens	123-130	
12471614-3	2003	Moreover, the beta(2)m-induced release of cytochrome c and AIF from the mitochondria in CCRF-HSB-2 cells was caspase-independent, since Z-VAD-fmk, a general inhibitor of caspases, did not block the release of these factors.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	136-145	beta-2-microglobulin	Homo sapiens	14-22	
12471614-4	2003	However, Z-VAD-fmk treatment significantly blocked beta(2)m-induced apoptosis, while Western blot analysis revealed that caspases-1, -2, -3, -6, -7, -8 and -9 are not activated during beta(2)m-induced apoptosis in these cells.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	9-18	beta-2-microglobulin	Homo sapiens	51-59	
11704825-7	2001	Additionally, Z-VAD-fmk, a general inhibitor of caspases which inhibited cytochrome c release in HL-60 and HL-60/VCR cells, had no effect on AIF release in any of these cell lines, but inhibited beta(2)m-induced apoptosis in all three cell lines.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	14-23	beta-2-microglobulin	Homo sapiens	195-203