PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19498109-3 2009 RIP3 did not affect RIP1-mediated apoptosis but was required for RIP1-mediated necrosis and the enhancement of necrosis by the caspase inhibitor zVAD. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 145-149 receptor-interacting serine-threonine kinase 3 Mus musculus 0-4 25980180-8 2015 In summary, functional disruption of HSP90 by DMAG destabilized necroptosis proteins RIP1 and RIP3, which in turn regulated zVAD- and TNFalpha-induced necroptosis. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 124-128 receptor-interacting serine-threonine kinase 3 Mus musculus 94-98 24874734-5 2014 Treatment with pan-caspase inhibitor ZVAD blocked the activation of caspase-8 and reduced the number of apoptotic nuclei, while increasing levels of RIP1, RIP3, and necrotic OHCs. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 37-41 receptor-interacting serine-threonine kinase 3 Mus musculus 155-159 23846218-4 2013 We report here that microglia activated through Toll-like receptors (TLRs) undergo RIP1/RIP3-dependent programmed necrosis (necroptosis) when exposed to the pan caspase inhibitor zVAD-fmk. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 179-187 receptor-interacting serine-threonine kinase 3 Mus musculus 88-92 24751948-2 2014 The L929 cell death induced by the pan-caspase inhibitor benzyloxycarbonyl-Val-Ala-Asp-(OMe)-fluoromethyl ketone (zVAD) was shown to be an autophagy-mediated death for which RIP1 and RIP3 were both required. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 114-118 receptor-interacting serine-threonine kinase 3 Mus musculus 183-187 24751948-7 2014 By the use of small hairpin RNAs and chemical inhibitors, we further demonstrated that zVAD-induced autophagy requires not only RIP1, RIP3, PI3KC3 and Beclin-1, but also RGS19 and GNAI3, and this autophagy is required for zVAD-induced TNF production. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 87-91 receptor-interacting serine-threonine kinase 3 Mus musculus 134-138 24577082-8 2014 TNFalpha/zVAD treatment induced cell death within 4 h. Cell death was preceded by RIPK1-RIPK3-pAkt assembly, and phosphorylation of Thr-308 and Thr473 of AKT and its direct substrate glycogen synthase kinase-3beta, as well as mTOR and its direct substrate S6 ribosomal protein (S6), suggesting activation of Akt/mTOR pathways. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 9-13 receptor-interacting serine-threonine kinase 3 Mus musculus 88-93 23584955-6 2014 Therefore, the protective effect of GA on zVAD/TNFalpha-stimulated necrosis might be attributed to RIP3, not RIP1, down-regulation. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 42-46 receptor-interacting serine-threonine kinase 3 Mus musculus 99-103 23584955-9 2014 Taken together, the results indicate that RIP1 and RIP3 can independently mediate death signals being transduced by two different death stimuli, zVAD and TNFalpha. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 145-149 receptor-interacting serine-threonine kinase 3 Mus musculus 51-55 31253195-5 2019 In mice, we determined whether plasma and lung tissue RIPK3 levels rise concomitantly 4 h after injection with lipopolysaccharide and ZVAD-FMK, an apoptosis inhibitor. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 134-142 receptor-interacting serine-threonine kinase 3 Mus musculus 54-59 31253195-9 2019 Mice injected with lipopolysaccharide and ZVAD-FMK had significantly higher plasma (p < 0.001) and lung (p = 0.005) RIPK3 than control mice. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 42-50 receptor-interacting serine-threonine kinase 3 Mus musculus 116-121 28649853-2 2018 Small-molecule analogues of second mitochondria-derived activator of caspase (SMAC) mimetic in association with mixed lineage kinase domain-like protein (MLKL)-pDNA and z-VAD-fmk have shown ideal antitumor effects in colon cancer cells in vitro via induction of RIP3-dependent necroptosis. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 169-178 receptor-interacting serine-threonine kinase 3 Mus musculus 262-266 29170425-4 2017 In this study, TNFalpha activated caspase pathway and induced cell death in RIP3 knockdown L929 cells, and the RIP3-independent cell death had been blocked by Z-VAD-FMK (pan-caspase inhibitor) or caspase 8 knockdown, demonstrating that RIP3 knockdown switched TNFalpha-induced necroptosis to caspase-dependent apoptosis. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 159-168 receptor-interacting serine-threonine kinase 3 Mus musculus 76-80 29170425-4 2017 In this study, TNFalpha activated caspase pathway and induced cell death in RIP3 knockdown L929 cells, and the RIP3-independent cell death had been blocked by Z-VAD-FMK (pan-caspase inhibitor) or caspase 8 knockdown, demonstrating that RIP3 knockdown switched TNFalpha-induced necroptosis to caspase-dependent apoptosis. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 159-168 receptor-interacting serine-threonine kinase 3 Mus musculus 111-115 29170425-4 2017 In this study, TNFalpha activated caspase pathway and induced cell death in RIP3 knockdown L929 cells, and the RIP3-independent cell death had been blocked by Z-VAD-FMK (pan-caspase inhibitor) or caspase 8 knockdown, demonstrating that RIP3 knockdown switched TNFalpha-induced necroptosis to caspase-dependent apoptosis. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 159-168 receptor-interacting serine-threonine kinase 3 Mus musculus 111-115 27834956-5 2017 In addition, RIP3 or MLKL knockout mouse embryonic fibroblasts (MEFs) are protected from BV6/Dexa/zVAD.fmk-induced cell death. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 98-102 receptor-interacting serine-threonine kinase 3 Mus musculus 13-17