PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17291719-6	2007	However, inhibition of caspases with zVAD-fmk resulted in strong inhibition of all these signalling pathways in Colo357-BclxL, but enhanced NFkappaB and JNK signalling in PancTuI cells.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	37-45	BCL2 like 1	Homo sapiens	120-125	
19726787-4	2009	Overexpression of the antiapoptotic protein Bcl-XL, alone or in combination with the inhibitor Z-VAD-FMK, attenuated caspase activation in HeLa cells exposed to doxorubicin, etoposide, or cell death siRNA.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	95-104	BCL2 like 1	Homo sapiens	44-50	
10793331-7	2000	The pretreatment of cells with pan-caspase inhibitor Z-VAD-fmk markedly prevented CBDCA-mediated cytotoxicity/apoptosis and the modulation of Bcl-2 family proteins (generation of p18 Bax-alpha and p16 Bcl-x(L) ) with only slight prevention of decline of Deltapsi(m).	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	53-62	BCL2 like 1	Homo sapiens	201-209	
16215673-5	2005	However, when Apo2L/TRAIL was combined with the Bcl-xL inhibitor, BH3I-2", it induced apoptosis synergistically through activation of Caspase-8 and the proapoptotic Bcl-2 family member Bid, resulting in the activation of effector Caspase-3 and proteolytic cleavage of Poly(ADP-ribose) polymerase, events that were blocked by the pan-caspase inhibitor zVAD-fmk.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	351-359	BCL2 like 1	Homo sapiens	48-54	
15561723-6	2005	The appearance of hypoxia-induced channels was also prevented by the caspase/cysteine protease inhibitor benzyloxycarbonyl-VAD-fluoromethyl ketone (Z-VAD-fmk), which inhibits proteolysis of BCL-xL during hypoxia.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	148-157	BCL2 like 1	Homo sapiens	190-196	
15389288-4	2004	Adenoviral X-linked inhibitor of apoptosis (XIAP) gene transfer, or exposure to the caspase inhibitor, benzyloxycarbonyl-Val-Ala-DL-Asp-fluoro-methylketone zVAD-fmk, blocks caspase-7 and PARP processing, but not cell death, whereas BCL-X(L) blocks not only caspase-7 and PARP processing but also cell death.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	156-164	BCL2 like 1	Homo sapiens	232-240	
10913120-8	2000	Bcl-x(L) cooperates with Z-VAD-fmk by blocking the Type II pathway at the level of cytochrome c release.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	25-34	BCL2 like 1	Homo sapiens	0-8	
12652655-8	2003	Interestingly, Z-VAD-FMK blocked U0126-induced down-regulation of Bcl-xL protein and apoptosis, strongly suggesting that Bcl-xL expression is regulated by caspases which lies downstream of ERK activation pathway in EPO signaling.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	15-24	BCL2 like 1	Homo sapiens	66-72	
12652655-8	2003	Interestingly, Z-VAD-FMK blocked U0126-induced down-regulation of Bcl-xL protein and apoptosis, strongly suggesting that Bcl-xL expression is regulated by caspases which lies downstream of ERK activation pathway in EPO signaling.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	15-24	BCL2 like 1	Homo sapiens	121-127