PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24874734-5 2014 Treatment with pan-caspase inhibitor ZVAD blocked the activation of caspase-8 and reduced the number of apoptotic nuclei, while increasing levels of RIP1, RIP3, and necrotic OHCs. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 37-41 receptor (TNFRSF)-interacting serine-threonine kinase 1 Mus musculus 149-153 24751948-2 2014 The L929 cell death induced by the pan-caspase inhibitor benzyloxycarbonyl-Val-Ala-Asp-(OMe)-fluoromethyl ketone (zVAD) was shown to be an autophagy-mediated death for which RIP1 and RIP3 were both required. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 114-118 receptor (TNFRSF)-interacting serine-threonine kinase 1 Mus musculus 174-178 24751948-7 2014 By the use of small hairpin RNAs and chemical inhibitors, we further demonstrated that zVAD-induced autophagy requires not only RIP1, RIP3, PI3KC3 and Beclin-1, but also RGS19 and GNAI3, and this autophagy is required for zVAD-induced TNF production. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 87-91 receptor (TNFRSF)-interacting serine-threonine kinase 1 Mus musculus 128-132 23584955-9 2014 Taken together, the results indicate that RIP1 and RIP3 can independently mediate death signals being transduced by two different death stimuli, zVAD and TNFalpha. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 145-149 receptor (TNFRSF)-interacting serine-threonine kinase 1 Mus musculus 42-46 24577082-8 2014 TNFalpha/zVAD treatment induced cell death within 4 h. Cell death was preceded by RIPK1-RIPK3-pAkt assembly, and phosphorylation of Thr-308 and Thr473 of AKT and its direct substrate glycogen synthase kinase-3beta, as well as mTOR and its direct substrate S6 ribosomal protein (S6), suggesting activation of Akt/mTOR pathways. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 9-13 receptor (TNFRSF)-interacting serine-threonine kinase 1 Mus musculus 82-87 23000518-4 2012 Moreover, pan-caspase inhibitor z-VAD-fmk (zVAD) increased RIP1 expression and exacerbated TNFalpha-induced mitochondrial dysfunction and ROS production, indicating that RIP1 led to mitochondrial dysfunction and ROS production. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 32-41 receptor (TNFRSF)-interacting serine-threonine kinase 1 Mus musculus 59-63 23846218-4 2013 We report here that microglia activated through Toll-like receptors (TLRs) undergo RIP1/RIP3-dependent programmed necrosis (necroptosis) when exposed to the pan caspase inhibitor zVAD-fmk. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 179-187 receptor (TNFRSF)-interacting serine-threonine kinase 1 Mus musculus 83-87 23000518-4 2012 Moreover, pan-caspase inhibitor z-VAD-fmk (zVAD) increased RIP1 expression and exacerbated TNFalpha-induced mitochondrial dysfunction and ROS production, indicating that RIP1 led to mitochondrial dysfunction and ROS production. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 32-41 receptor (TNFRSF)-interacting serine-threonine kinase 1 Mus musculus 170-174 23000518-4 2012 Moreover, pan-caspase inhibitor z-VAD-fmk (zVAD) increased RIP1 expression and exacerbated TNFalpha-induced mitochondrial dysfunction and ROS production, indicating that RIP1 led to mitochondrial dysfunction and ROS production. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 43-47 receptor (TNFRSF)-interacting serine-threonine kinase 1 Mus musculus 59-63 23000518-4 2012 Moreover, pan-caspase inhibitor z-VAD-fmk (zVAD) increased RIP1 expression and exacerbated TNFalpha-induced mitochondrial dysfunction and ROS production, indicating that RIP1 led to mitochondrial dysfunction and ROS production. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 43-47 receptor (TNFRSF)-interacting serine-threonine kinase 1 Mus musculus 170-174 20125124-6 2010 Interestingly, knockdown of HtrA2/Omi afforded protection against IL-3 withdrawal-induced death in the presence of zVAD-fmk, demonstrating a role for HtrA2/Omi in caspase-independent cell death during growth factor withdrawal by cleaving RIP1. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 115-123 receptor (TNFRSF)-interacting serine-threonine kinase 1 Mus musculus 238-242 21853090-8 2011 Strikingly, we found that siRNA-mediated silencing of RIP1 inhibited zVAD-fmk induced necrosis, but not TNF-induced necrosis. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 69-77 receptor (TNFRSF)-interacting serine-threonine kinase 1 Mus musculus 54-58 16874073-5 2006 The different sensitivity to z-VAD-fmk is largely based on differential expression of receptor-interacting protein 1 (RIP1). benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 29-38 receptor (TNFRSF)-interacting serine-threonine kinase 1 Mus musculus 86-116 16874073-5 2006 The different sensitivity to z-VAD-fmk is largely based on differential expression of receptor-interacting protein 1 (RIP1). benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 29-38 receptor (TNFRSF)-interacting serine-threonine kinase 1 Mus musculus 118-122 16537794-8 2006 Further evidence indicated that the expression level of receptor-interacting protein 1 (RIP1) mediates the sensitivity to z-VAD-fmk. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 122-131 receptor (TNFRSF)-interacting serine-threonine kinase 1 Mus musculus 56-86 16537794-8 2006 Further evidence indicated that the expression level of receptor-interacting protein 1 (RIP1) mediates the sensitivity to z-VAD-fmk. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 122-131 receptor (TNFRSF)-interacting serine-threonine kinase 1 Mus musculus 88-92 16537794-10 2006 The combination of z-VAD-fmk and TNFalpha, but not TNFalpha alone, induced SMCs necrosis via a mechanism that required RIP1 expression. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 19-28 receptor (TNFRSF)-interacting serine-threonine kinase 1 Mus musculus 119-123 32979304-1 2020 Necroptosis induction in vitro often requires caspase-8 (Casp8) inhibition by zVAD because pro-Casp8 cleaves RIP1 to disintegrate the necrosome. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 78-82 receptor (TNFRSF)-interacting serine-threonine kinase 1 Mus musculus 109-113 25980180-7 2015 In contrast, the protective effect of DMAG on zVAD-induced cytotoxicity could be partly explained by the fact that zVAD mediates cytotoxicity via a RIP1 -dependent route. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 46-50 receptor (TNFRSF)-interacting serine-threonine kinase 1 Mus musculus 148-152 25980180-7 2015 In contrast, the protective effect of DMAG on zVAD-induced cytotoxicity could be partly explained by the fact that zVAD mediates cytotoxicity via a RIP1 -dependent route. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 115-119 receptor (TNFRSF)-interacting serine-threonine kinase 1 Mus musculus 148-152 30074231-9 2019 Interestingly, parkin knockdown protected BV-2 cells from zVAD-induced necroptosis, which may depend on the higher RIP1 ubiquitination levels detected in siRNA-PARK2 transfected cells. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 58-62 receptor (TNFRSF)-interacting serine-threonine kinase 1 Mus musculus 115-119 28770700-4 2018 In the mouse hepatocyte cell line, TIB-73 cells, TNF-alpha/cycloheximide (T/C) induced RIP1/3 binding only when caspase activity was suppressed by the caspase-specific inhibitor z-VAD-fmk (zVAD). benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 178-187 receptor (TNFRSF)-interacting serine-threonine kinase 1 Mus musculus 87-91 28770700-5 2018 T/C/zVAD-induced RIP1/3 binding was inhibited by necrostatin-1 (Nec-1), an allosteric inhibitor of RIP1. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 4-8 receptor (TNFRSF)-interacting serine-threonine kinase 1 Mus musculus 17-21 28770700-5 2018 T/C/zVAD-induced RIP1/3 binding was inhibited by necrostatin-1 (Nec-1), an allosteric inhibitor of RIP1. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 4-8 receptor (TNFRSF)-interacting serine-threonine kinase 1 Mus musculus 99-103 27605011-6 2016 Primary hepatocytes isolated from RIPK1-knockdown mice were sensitized to TNF-induced cell death that was completely inhibited by adding zVAD.fmk. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 137-145 receptor (TNFRSF)-interacting serine-threonine kinase 1 Mus musculus 34-39 27616656-5 2016 Inhibition of receptor-interacting protein kinase (RIP)1 by necrostatin 1 partially inhibited TNF-alpha/ZVAD-induced necrosis in primary hepatocytes. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 104-108 receptor (TNFRSF)-interacting serine-threonine kinase 1 Mus musculus 14-56