PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28396364-7	2017	In fact, activation of several proapoptotic markers (caspase-9, caspase-3, and PARP) and reversion of the cytotoxic effect upon treatment with an apoptosis inhibitor (Z-VAD-FMK) were observed.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	167-176	caspase 9	Mus musculus	53-62	
33396178-8	2021	Inhibition of caspase with pan-caspase inhibitor, Z-VAD-FMK, prevented MC3T3-E1 subclone 14 cells from cadmium-induced reduction of Runx2, STC2, caspase 9, and accumulation of cleaved PARP and cleaved caspase 3.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	50-59	caspase 9	Mus musculus	14-21	
33396178-8	2021	Inhibition of caspase with pan-caspase inhibitor, Z-VAD-FMK, prevented MC3T3-E1 subclone 14 cells from cadmium-induced reduction of Runx2, STC2, caspase 9, and accumulation of cleaved PARP and cleaved caspase 3.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	50-59	caspase 9	Mus musculus	31-38	
33396178-8	2021	Inhibition of caspase with pan-caspase inhibitor, Z-VAD-FMK, prevented MC3T3-E1 subclone 14 cells from cadmium-induced reduction of Runx2, STC2, caspase 9, and accumulation of cleaved PARP and cleaved caspase 3.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	50-59	caspase 9	Mus musculus	145-154	
23820203-4	2013	Finally, the GA-induced cell apoptosis was evaluated by flow cytometry in the present of caspase inhibitors Z-VAD-FMK and Ac-LEHD-FMK, respectively.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	108-117	caspase 9	Mus musculus	89-96	
17403866-2	2007	In the cells treated with z-VAD-fmk, activation of caspase-8, caspase-3/7, and caspase-9 was clearly suppressed, and DNA fragmentation of the infected cells was also reduced.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	26-35	caspase 9	Mus musculus	79-88	
22613767-0	2012	zVAD-fmk upregulates caspase-9 cleavage and activity in etoposide-induced cell death of mouse embryonic fibroblasts.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	0-8	caspase 9	Mus musculus	21-30	
22613767-10	2012	In MEFs, zVAD-fmk increased p53-dependent loss of DeltaPsim, cytochrome c release and caspase-9 activity.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	9-17	caspase 9	Mus musculus	86-95	
22613767-11	2012	Indeed, zVAD-fmk inhibited effector caspases (caspases-3, -6, -7) as expected but increased caspase-9 cleavage and activity in etoposide-treated MEFs.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	8-16	caspase 9	Mus musculus	92-101	
22613767-14	2012	Invalidation of caspase-9 did not inhibit mitochondrial membrane depolarization but suppressed zVAD-fmk amplification of this process.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	95-103	caspase 9	Mus musculus	16-25	
22613767-15	2012	Altogether, our data suggest that caspase-9 activity is up-regulated by zVAD-fmk and is involved in an amplification loop of etoposide-induced cell death at the mitochondrial level in MEFs.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	72-80	caspase 9	Mus musculus	34-43	
19035350-5	2008	The inhibition of caspase activity by Z-VAD-fmk accelerated the transition from metaphase I to metaphase II, and caspase-9 and caspase-3 were detected along the meiotic spindle.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	38-47	caspase 9	Mus musculus	80-122	
16675471-9	2006	Both HA- and RES-induced cleavage of caspase-9 and caspase-3 and PARP were completely blocked by a pan caspase inhibitor, Z-VAD-FMK.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	122-131	caspase 9	Mus musculus	37-46	
16505011-8	2006	This death was caspase dependent, as shown by IHC and caspase inhibition with zVAD-fmk.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	78-86	caspase 9	Mus musculus	15-22	
16505011-8	2006	This death was caspase dependent, as shown by IHC and caspase inhibition with zVAD-fmk.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	78-86	caspase 9	Mus musculus	54-61	
12857937-5	2003	Silica-induced apoptosis and caspase 3 activation were, in part, caspase 9 dependent, as determined by their sensitivity to either a general caspase inhibitor (Z-VAD-FMK) or a specific caspase 9 inhibitor (Z-LEHD-FMK).	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	160-169	caspase 9	Mus musculus	65-74	
12581736-7	2003	The dominant negative form of FADD and z-VAD-fmk inhibited caspase-8, caspase-9, Bid processing, cytochrome c release, and DNA fragmentation induced by ER stress, suggesting that caspase-8 and caspase-9 are the main caspases involved in ER stress-mediated apoptosis of P19-36/12 (-) cells.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	39-48	caspase 9	Mus musculus	70-79	
12581736-7	2003	The dominant negative form of FADD and z-VAD-fmk inhibited caspase-8, caspase-9, Bid processing, cytochrome c release, and DNA fragmentation induced by ER stress, suggesting that caspase-8 and caspase-9 are the main caspases involved in ER stress-mediated apoptosis of P19-36/12 (-) cells.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	39-48	caspase 9	Mus musculus	193-202