PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15123887-9 2004 Our data therefore suggest that there is a novel, caspase-8-independent, Z-VAD-FMK-inhibitable, apoptotic pathway in 12B1-D1 cells that targets mitochondria directly. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 73-82 caspase 8 Mus musculus 50-59 23022514-5 2012 The p53 inhibitor pifithrin-mu and pan caspase inhibitor Z-VAD-FMK suppressed rRNA cleavage induced by anisomycin, SG and ricin, indicating that these ribotoxins shared with DON a conserved downstream pathway. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 57-66 caspase 8 Mus musculus 39-46 19765549-6 2010 However, the ITR-284-induced caspase-8/-9 and -3 activities can be blocked by pan-caspase inhibitor (Z-VAD-FMK). benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 101-110 caspase 8 Mus musculus 29-48 19736292-4 2009 Pre-treatment with broad-spectrum caspase inhibitor Z-VAD-FMK, caspase-3 inhibitor Ac-DEVD-CHO and caspase-8 inhibitor Z-IETD-FMK prevented the change in MMP and DNA fragmentation, suggesting caspase-dependent apoptosis of rYopJ-treated macrophages. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 52-61 caspase 8 Mus musculus 34-41 21127402-8 2011 We found caspase 8 is associated with c-Src at the resting state, and upon zVAD treatment this association was decreased and accompanied by c-Src activation. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 75-79 caspase 8 Mus musculus 9-18 20431342-9 2010 We found caspase 8 is associated with c-Src at resting state, and upon zVAD treatment this association is decreased and accompanied by c-Src activation. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 71-75 caspase 8 Mus musculus 9-18 17873911-10 2008 Death of BIK-expressing Bcl-2-/- cells treated with zVAD-fmk was increased under caspase-8 depletion. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 52-60 caspase 8 Mus musculus 81-90 15122760-9 2004 The caspase inhibitors benzyloxycarbonyl-Val-Ala-Asp-(OMe)-fluoromethylketone (zVAD-fmk) and benzyloxycarbonyl-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-chloromethylketone (zDEVD-fmk), as well as depletion of intracellular ATP by fructose prevented CPT/TNF-induced apoptosis. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 79-87 caspase 8 Mus musculus 4-11 32979304-1 2020 Necroptosis induction in vitro often requires caspase-8 (Casp8) inhibition by zVAD because pro-Casp8 cleaves RIP1 to disintegrate the necrosome. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 78-82 caspase 8 Mus musculus 46-55 12581736-7 2003 The dominant negative form of FADD and z-VAD-fmk inhibited caspase-8, caspase-9, Bid processing, cytochrome c release, and DNA fragmentation induced by ER stress, suggesting that caspase-8 and caspase-9 are the main caspases involved in ER stress-mediated apoptosis of P19-36/12 (-) cells. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 39-48 caspase 8 Mus musculus 59-68 12581736-7 2003 The dominant negative form of FADD and z-VAD-fmk inhibited caspase-8, caspase-9, Bid processing, cytochrome c release, and DNA fragmentation induced by ER stress, suggesting that caspase-8 and caspase-9 are the main caspases involved in ER stress-mediated apoptosis of P19-36/12 (-) cells. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 39-48 caspase 8 Mus musculus 179-188 12581736-7 2003 The dominant negative form of FADD and z-VAD-fmk inhibited caspase-8, caspase-9, Bid processing, cytochrome c release, and DNA fragmentation induced by ER stress, suggesting that caspase-8 and caspase-9 are the main caspases involved in ER stress-mediated apoptosis of P19-36/12 (-) cells. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 39-48 caspase 8 Mus musculus 216-224 12589031-6 2003 The pan-caspase inhibitor Z-VAD-fmk did not inhibit flavopiridol-induced apoptosis. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 26-35 caspase 8 Mus musculus 8-15 12538035-5 2003 CMT-1 and CMT-8 activate mainly caspase-8 as attested by the inhibitory effects of Z-VAD-fmk and Z-IEDT-fmk on CMT-induced apoptosis. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 83-92 caspase 8 Mus musculus 32-41 11953831-3 2002 The broad spectrum caspase inhibitor zVADfmk and caspase-9 inhibitor zLEDHfmk inhibited apoptosis and improved cell viability when administrated to cells 1 h before exposure to declopramide, whereas the caspase-8 inhibitor zIEDHfmk had less effect. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 37-44 caspase 8 Mus musculus 203-212 9839279-6 1998 Peptide inhibitors of caspases such as zVAD-fmk (which inhibits caspases 8 and 9) and DEVD-CHO (which inhibits caspase 3 and related caspases) prevented CsA-induced apoptosis in MCT cells, although zVAD-fmk was effective at lower concentrations. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 39-47 caspase 8 Mus musculus 22-30 9839279-6 1998 Peptide inhibitors of caspases such as zVAD-fmk (which inhibits caspases 8 and 9) and DEVD-CHO (which inhibits caspase 3 and related caspases) prevented CsA-induced apoptosis in MCT cells, although zVAD-fmk was effective at lower concentrations. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 39-47 caspase 8 Mus musculus 64-80 9839279-6 1998 Peptide inhibitors of caspases such as zVAD-fmk (which inhibits caspases 8 and 9) and DEVD-CHO (which inhibits caspase 3 and related caspases) prevented CsA-induced apoptosis in MCT cells, although zVAD-fmk was effective at lower concentrations. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 198-206 caspase 8 Mus musculus 22-30 32979304-1 2020 Necroptosis induction in vitro often requires caspase-8 (Casp8) inhibition by zVAD because pro-Casp8 cleaves RIP1 to disintegrate the necrosome. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 78-82 caspase 8 Mus musculus 57-62 32979304-1 2020 Necroptosis induction in vitro often requires caspase-8 (Casp8) inhibition by zVAD because pro-Casp8 cleaves RIP1 to disintegrate the necrosome. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 78-82 caspase 8 Mus musculus 95-100 32979304-7 2020 Phosphorylation of pro-Casp8 at Thr265 can substitute for zVAD to permit necroptosis in vitro. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 58-62 caspase 8 Mus musculus 23-28 31028855-15 2019 Furthermore, ASC and LPS-cotreated cells which a caspase inhibitor, z-VAD-fmk, was pretreated, showed the decreased cell viability compared with control cells without the inhibitor. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 68-77 caspase 8 Mus musculus 49-56 27350283-9 2016 Since caspase-8 has been reported to enhance cellular migration by Tyr380 phosphorylation via Src, we examined Tyr380 phosphorylation of caspase-8 in ASC-knockdown cells and found it to be elevated in ASC-knockdown cells but attenuated by z-VAD-fmk or z-IETD-fmk. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 239-248 caspase 8 Mus musculus 6-15 27739412-5 2016 Moreover, co-treatment with Z-VAD-fmk (a pan-caspase inhibitor) inhibited apoptosis by completely inhibiting caspases, resulting in a shift from apoptosis to necroptosis. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 28-37 caspase 8 Mus musculus 109-117 27350283-9 2016 Since caspase-8 has been reported to enhance cellular migration by Tyr380 phosphorylation via Src, we examined Tyr380 phosphorylation of caspase-8 in ASC-knockdown cells and found it to be elevated in ASC-knockdown cells but attenuated by z-VAD-fmk or z-IETD-fmk. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 239-248 caspase 8 Mus musculus 137-146 24874734-5 2014 Treatment with pan-caspase inhibitor ZVAD blocked the activation of caspase-8 and reduced the number of apoptotic nuclei, while increasing levels of RIP1, RIP3, and necrotic OHCs. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 37-41 caspase 8 Mus musculus 19-26 24874734-5 2014 Treatment with pan-caspase inhibitor ZVAD blocked the activation of caspase-8 and reduced the number of apoptotic nuclei, while increasing levels of RIP1, RIP3, and necrotic OHCs. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 37-41 caspase 8 Mus musculus 68-77 25391371-13 2015 In addition, z-VAD-fmk, a universal inhibitor of caspases, prevented activation of cleavage caspase-3 and abrogates cell death induced by thiostrepton treatment. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 13-22 caspase 8 Mus musculus 49-57