PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23540413-5	2013	zVADfmk was used to determine if it could inhibit activation of caspases-2, -3, and -8 in dDCN following 6OHD-mediated stress.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	0-7	caspase 2	Homo sapiens	64-86	
23540413-7	2013	Additionally, WB analysis revealed that caspases-2, -3, and -8 activation was reduced by zVADfmk in 6OHD-treated cells.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	89-96	caspase 2	Homo sapiens	40-62	
11137534-2	2001	A one-day treatment with OA induced accumulation of the 85kDa poly(ADP-ribose) polymerase (PARP) fragment in cell lysates but the response was prevented if cells were treated with OA in the presence of the caspase inhibitors Z-VAD-FMK and Z-DEVD-FMK.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	225-234	caspase 2	Homo sapiens	206-213	
17426447-6	2007	The NG-18-induced apoptosis was blocked completely by a pan-caspase inhibitor Z-VAD-FMK, indicating that caspases were functionally and actively involved in this process.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	78-87	caspase 2	Homo sapiens	60-67	
17426447-6	2007	The NG-18-induced apoptosis was blocked completely by a pan-caspase inhibitor Z-VAD-FMK, indicating that caspases were functionally and actively involved in this process.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	78-87	caspase 2	Homo sapiens	105-113	
15825194-6	2005	Pretreatment for 90 min with either the pan-caspase inhibitor Z-VAD-FMK or the caspase-2-selective inhibitor Z-VDVAD-FMK inhibited thapsigargin-stimulated cell death, resulting in the number of viable cells being 115.6% +/- 5.3% (P < 0.001) and 69.3% +/- 2.9% (P < 0.01), respectively, of starting-time control.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	62-71	caspase 2	Homo sapiens	44-51	
12907619-6	2003	Proteolytic cleavage of caspase-2, which is poorly inhibited by zVAD-fmk, was concomitant with HDACI-induced death; however, full processing of caspase-2 to the p19 active form was blocked by Bcl-2.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	64-72	caspase 2	Homo sapiens	24-33	
23474846-7	2013	Breaking radio-/ chemoresistance in NHL cells using [Bi-213]anti-CD20 depends on caspase activation as demonstrated by complete inhibition of [Bi-213]anti-CD20-induced apoptosis with zVAD.fmk, a specific inhibitor of caspases activation.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	183-187	caspase 2	Homo sapiens	81-88	
15500642-4	2004	The caspase inhibitor zVAD-fmk prevented both the cell detachment and protein cleavage, indicating the function of caspases in these events.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	22-30	caspase 2	Homo sapiens	4-11	
15500642-4	2004	The caspase inhibitor zVAD-fmk prevented both the cell detachment and protein cleavage, indicating the function of caspases in these events.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	22-30	caspase 2	Homo sapiens	115-123	
11137534-6	2001	The possible interference of caspase inhibitors on cell death was also evaluated, and we found that both Z-VAD-FMK and Z-DEVD-FMK could contribute different extents of protection of MCF-7 and HeLa cells from toxic effects caused by OA.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	105-114	caspase 2	Homo sapiens	29-36	
9624143-7	1998	Although the specific caspase inhibitory peptides Z-VAD-fmk and Z-DEVD-fmk prevented apoptosis of MCF-7 cells, we were unable to detect activation of caspases 2 and 7, which are known to be inhibited by Z-DEVD-fmk.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	50-59	caspase 2	Homo sapiens	22-29	
9766499-6	1998	Induction of apoptosis and processing of all the caspases was inhibited by the cell permeable caspase inhibitor, benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethyl ketone (Z-VAD.fmk).	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	170-179	caspase 2	Homo sapiens	49-57	
10772942-4	2000	Here we show that the pan-caspase, tripeptide inhibitor, benzyloxycarbonyl-Val-Ala-Asp (Ome) fluoromethylketone (z-VAD-FMK), inhibited the activation of caspase-2, -3, -7, and -8, and subsequently apoptosis in Jurkat T lymphocytes induced by agonistic anti-Fas.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	113-122	caspase 2	Homo sapiens	26-33	
10772942-4	2000	Here we show that the pan-caspase, tripeptide inhibitor, benzyloxycarbonyl-Val-Ala-Asp (Ome) fluoromethylketone (z-VAD-FMK), inhibited the activation of caspase-2, -3, -7, and -8, and subsequently apoptosis in Jurkat T lymphocytes induced by agonistic anti-Fas.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	113-122	caspase 2	Homo sapiens	153-178	
10224236-4	1999	The general caspase inhibitor z-VAD-fmk, but not the CPP32 family inhibitor Ac-DEVD-CHO, blocked anti- micro-induced apoptosis, indicating that a caspase not belonging to the CPP32-like family is also implicated in anti- micro-triggered apoptosis.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	30-39	caspase 2	Homo sapiens	12-19	
10224236-4	1999	The general caspase inhibitor z-VAD-fmk, but not the CPP32 family inhibitor Ac-DEVD-CHO, blocked anti- micro-induced apoptosis, indicating that a caspase not belonging to the CPP32-like family is also implicated in anti- micro-triggered apoptosis.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	30-39	caspase 2	Homo sapiens	146-153	
25119188-4	2015	The SAHA-induced cleavage of HSP90 was blocked by a pan-caspase inhibitor, z-VAD-fmk, implying that the process is dependent on caspase activity.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	75-84	caspase 2	Homo sapiens	56-63	
9343396-8	1997	Furthermore, inhibition of Sp1 cleavage by ZVAD-fmk and ZDEVD-fmk suggests that caspases are directly involved in this event.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	43-51	caspase 2	Homo sapiens	80-88	
25119188-4	2015	The SAHA-induced cleavage of HSP90 was blocked by a pan-caspase inhibitor, z-VAD-fmk, implying that the process is dependent on caspase activity.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	75-84	caspase 2	Homo sapiens	128-135