PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12065092-7 2002 Furthermore, the Gyp-induced apoptosis was markedly blocked by the broad-spectrum caspase inhibitor, z-VAD-fmk. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 101-110 caspase 1 Homo sapiens 82-89 18662322-3 2008 ENZA-induced apoptosis involved cleavage of caspases 3, 8, and 9 and led to mitochondrial cytochrome c release and was strongly suppressed by the broad spectrum caspase inhibitor zVAD-fmk but only slightly by the expression of the viral caspase 1/8 inhibitor cytokine response modifier-A. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 179-187 caspase 1 Homo sapiens 44-51 15827328-6 2005 Resveratrol-induced DNA fragmentation can be completely blocked by either a general caspase inhibitor (Z-VAD-FMK) or a selective caspase-3 inhibitor (Z-DEVD-FMK), but not by a selective caspase-1 inhibitor. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 103-112 caspase 1 Homo sapiens 84-91 19069247-8 2008 The cell death was completely prevented by the pan caspase inhibitor benzyloxy carbonyl-Val-Ala-Asp- fluoromethyl-ketone (Z-VAD-FMK). benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 122-131 caspase 1 Homo sapiens 51-58 10974198-4 2000 These effects were prevented completely by the pan-caspase inhibitor z-Val-Ala-Asp-(OMe)-fluoromethylketone (z-VAD-fmk), thereby implicating the cysteine aspartase (caspase) cascade in the process. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 109-118 caspase 1 Homo sapiens 51-58 12529972-4 2002 Treatment with the general caspase inhibitor Z-VAD-fmk, as well as the caspase-1 inhibitor YVAD-CHO, significantly blocked beta 2m-induced apoptosis. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 45-54 caspase 1 Homo sapiens 27-34 11022849-3 2000 The presence of fairly low concentrations of VES inhibited the growth and DNA synthesis of HL-60 cells, and also induced their apoptosis via a mechanism that was inhibited by z-VAD-fluoromethylketone (z-VAD-fmk), an inhibitor of pan-caspases. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 175-199 caspase 1 Homo sapiens 233-241 11704825-7 2001 Additionally, Z-VAD-fmk, a general inhibitor of caspases which inhibited cytochrome c release in HL-60 and HL-60/VCR cells, had no effect on AIF release in any of these cell lines, but inhibited beta(2)m-induced apoptosis in all three cell lines. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 14-23 caspase 1 Homo sapiens 48-56 11179455-9 2001 Furthermore, paclitaxel-induced apoptosis and cleavage of beta-catenin and gamma-catenin were inhibited by the pan-caspase inhibitor Z-VAD-FMK and partially inhibited by the caspase-3 inhibitor Z-DEVD-FMK but were not affected by the caspase-1 inhibitor AC-YVAD-CMK. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 133-142 caspase 1 Homo sapiens 234-243 11181049-3 2001 Cytotoxic drug-induced apoptosisinvolves delayed activation of caspases 2, 7, and 9, but not 8 and 3, and is blocked by a broad spectrum caspase inhibitor, zVAD-fmk. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 156-164 caspase 1 Homo sapiens 63-71 10960761-4 2000 Incubation with z-DEVD-fmk and benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone (z-VAD-fmk) almost completely abrogated MMC-induced DNA fragmentation, indicating that activation of these caspases was crucially involved in MMC-induced apoptosis. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 81-90 caspase 1 Homo sapiens 187-195 10974198-4 2000 These effects were prevented completely by the pan-caspase inhibitor z-Val-Ala-Asp-(OMe)-fluoromethylketone (z-VAD-fmk), thereby implicating the cysteine aspartase (caspase) cascade in the process. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 109-118 caspase 1 Homo sapiens 165-172 10989191-9 2000 Activation of caspase-3/CPP32 and apoptosis upon growth factor withdrawal were inhibited/reduced by the caspase inhibitors, z-VAD-fmk and DEVD-CHO. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 124-133 caspase 1 Homo sapiens 14-21 10825467-8 2000 The general caspase inhibitor N-benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone and the specific caspase-8 inhibitor N-benzyloxycarbonyl-Ile-Glu(OMe)-Thr-Asp(OMe)-fluoromethylketone inhibited apoptosis, but specific caspase-1 and caspase-3 inhibitors did not. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 30-85 caspase 1 Homo sapiens 222-231 10892568-7 1999 The interleukin-1 converting enzyme (ICE) inhibitor z-VAD-fmk reduced apoptosis for low-, medium- and high-expressing constructs, whereas the CPP-32 inhibitor z-DEVD-fmk had no effect. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 52-61 caspase 1 Homo sapiens 4-35 10937621-6 2000 In all cases, the irreversible nonselective caspase inhibitor, Z-VAD-FMK, and the caspase-3-selective inhibitor, Ac-DMQD-CHO, inhibited DEVDase activity and apoptosis, whereas the caspase-1-selective inhibitor, Ac-YVAD-CHO, had no effect. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 63-72 caspase 1 Homo sapiens 180-189 10892568-7 1999 The interleukin-1 converting enzyme (ICE) inhibitor z-VAD-fmk reduced apoptosis for low-, medium- and high-expressing constructs, whereas the CPP-32 inhibitor z-DEVD-fmk had no effect. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 52-61 caspase 1 Homo sapiens 37-40 10047465-5 1999 In addition, p38 activation is dependent upon the activation of the caspase system since p38 activation is blocked by the pan ICE inhibitor Z-VAD fmk, which also inhibits CD437-mediated apoptosis and PARP cleavage in these cells. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 140-149 caspase 1 Homo sapiens 68-75 10381635-8 1999 The cell permeable tripeptide inhibitor of ICE family cysteine proteases, zVAD-fmk, suppressed Mn2+-induced apoptosis. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 74-82 caspase 1 Homo sapiens 43-46 10085120-4 1999 The caspase inhibitors benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone (zVAD-fmk) and benzyloxycarbonyl-Asp-Glu-Val-Asp-fluoromethylketone (zDEVD-fmk) protect cells against apoptosis and inhibit DEVD-specific caspase activity and PARP cleavage without affecting JNK1 and p38 MAPK activations. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 73-81 caspase 1 Homo sapiens 4-11 10096572-11 1999 This TGF-beta1-mediated apoptosis induction in TbetaRII transfectant cells was significantly protected by the caspase-1 inhibitor (zVAD-fmk) in a dose-dependent manner. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 131-139 caspase 1 Homo sapiens 110-119 10047465-5 1999 In addition, p38 activation is dependent upon the activation of the caspase system since p38 activation is blocked by the pan ICE inhibitor Z-VAD fmk, which also inhibits CD437-mediated apoptosis and PARP cleavage in these cells. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 140-149 caspase 1 Homo sapiens 126-129 9862416-3 1998 Under apoptotic conditions the cleavage of poly(ADP-ribose) polymerase (PARP) into the 85-kDa product is blocked by the caspase inhibitors benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone (z-VAD-fmk) and benzyloxycarbonyl-Asp-Glu-Val-Asp-fluoromethylketone (z-DEVD-fmk). benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 189-198 caspase 1 Homo sapiens 120-127 9834227-4 1998 Proteasome inhibitor-induced DNA fragmentation was associated with activation of caspase/ICE family cysteine protease(s) and was blocked by the caspase antagonist, zVADfmk. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 164-171 caspase 1 Homo sapiens 81-88 9834227-4 1998 Proteasome inhibitor-induced DNA fragmentation was associated with activation of caspase/ICE family cysteine protease(s) and was blocked by the caspase antagonist, zVADfmk. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 164-171 caspase 1 Homo sapiens 89-92 9834227-4 1998 Proteasome inhibitor-induced DNA fragmentation was associated with activation of caspase/ICE family cysteine protease(s) and was blocked by the caspase antagonist, zVADfmk. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 164-171 caspase 1 Homo sapiens 144-151 9894612-3 1998 Caspases-1, -3, -6 and -7 were shown to cleave fodrin to the 150 kDa fragment in vitro and all were inhibited by 10 microM zVAD-fmk. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 123-131 caspase 1 Homo sapiens 0-25 9642224-9 1998 In contrast, the CED-3/interleukin-1beta-converting enzyme (ICE) protease inhibitor Z-VADfmk efficiently suppressed Fas-induced apoptosis and only marginally inhibited PKC/Ras-mediated apoptosis. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 84-92 caspase 1 Homo sapiens 23-58 9642224-9 1998 In contrast, the CED-3/interleukin-1beta-converting enzyme (ICE) protease inhibitor Z-VADfmk efficiently suppressed Fas-induced apoptosis and only marginally inhibited PKC/Ras-mediated apoptosis. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 84-92 caspase 1 Homo sapiens 60-63 9334376-6 1997 We show that z-VAD-fmk, a tripeptide inhibitor of ICE homologues, can inhibit Fas-induced apoptosis of peripheral blood CD4(+) and CD8+ T cells from asymptomatic HIV+ individuals. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 13-22 caspase 1 Homo sapiens 50-53 9581784-6 1998 Z-VAD-FMK inhibited E1A-induced apoptosis in adenovirus-infected Hela cells, suggesting that the ICE family proteases are involved in this apoptosis pathway. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 0-9 caspase 1 Homo sapiens 97-100 9425165-6 1998 However, the protease CPP32, a downstream molecule of the CD95 pathway, was activated in UV-exposed HaCaT cells, and UV-induced apoptosis was blocked by the ICE protease inhibitor zVAD, implying that at least similar downstream events are involved in CD95- and UV-induced apoptosis. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 180-184 caspase 1 Homo sapiens 157-160 9357850-7 1997 Pretreatment of cells with 10 microM of the ICE inhibitor z-Val-Ala-Asp-fluoromethyl ketone and the cpp32beta inhibitor Asp-Glu-Val-Asp-fluoromethyl ketone completely blocked silica-induced apoptosis. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 58-91 caspase 1 Homo sapiens 44-47 9084431-4 1997 The ICE-like protease inhibitor benzyloxycarbonyl-Val-Ala-Asp (O-methyl)fluoromethyl ketone (zVAD-fmk) was found to be extremely effective at preventing staurosporine-induced death of cerebellar granule neurones and yet was completely ineffective in preventing K+ deprivation-induced death. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 93-101 caspase 1 Homo sapiens 4-7 9173887-5 1997 Whereas actin cleavage and nuclear/cell surface markers of apoptosis were co-ordinately diminished by zVAD-fmk, an inhibitor of the ICE-like family of proteases, only acetyl-leucyl-leucylnormethional, an inhibitor of calpains, was capable of completely inhibiting actin cleavage. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 102-110 caspase 1 Homo sapiens 132-135 9271410-10 1997 Moreover, both EGF-induced apoptosis and IFN-gamma-induced apoptosis were effectively blocked by Z-Val-Ala-Asp-fluoromethylketone (ZVAD) in all the cells tested, and studies from ICE-deficient cells indicated that ICE gene expression was necessary for IFN-gamma-induced apoptosis. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 97-129 caspase 1 Homo sapiens 214-217 9271410-10 1997 Moreover, both EGF-induced apoptosis and IFN-gamma-induced apoptosis were effectively blocked by Z-Val-Ala-Asp-fluoromethylketone (ZVAD) in all the cells tested, and studies from ICE-deficient cells indicated that ICE gene expression was necessary for IFN-gamma-induced apoptosis. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 131-135 caspase 1 Homo sapiens 214-217 9084431-5 1997 Staurosporine induced cleavage of the 116-kDa poly (ADP-ribose) polymerase enzyme, a substrate of ICE-like proteases, to the 85-kDa product, and this cleavage was also blocked by zVAD. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 179-183 caspase 1 Homo sapiens 98-101 9054391-9 1997 Pretreatment of the cells with benzyloxycarbonyl-Val-Ala-Asp-(OMe)-fluoromethylketone (zVAD.fmk), a tetrapeptide inhibitor of caspases, prevented the induction of apoptosis for 24 h. Even after 72 h of treatment, some cells were still alive and progressing through the cell cycle, suggesting that blockage of caspase activity is able to protect cells. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 87-95 caspase 1 Homo sapiens 126-134 9054391-9 1997 Pretreatment of the cells with benzyloxycarbonyl-Val-Ala-Asp-(OMe)-fluoromethylketone (zVAD.fmk), a tetrapeptide inhibitor of caspases, prevented the induction of apoptosis for 24 h. Even after 72 h of treatment, some cells were still alive and progressing through the cell cycle, suggesting that blockage of caspase activity is able to protect cells. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 87-95 caspase 1 Homo sapiens 126-133 8681377-3 1996 FLICE binds to the death effector domain of FADD and upon overexpression induces apoptosis that is blocked by the ICE family inhibitors, CrmA and z-VAD-fmk. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 146-155 caspase 1 Homo sapiens 2-5 8972182-4 1997 Fas has been shown to require ICE (interleukin-1 beta-converting enzyme) family proteases to induce apoptosis from studies utilizing the cowpox ICE inhibitor protein CrmA, the synthetic tetrapeptide ICE inhibitor YVAD-CMK, and the tripeptide pan-ICE inhibitor Z-VAD-FMK. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 260-269 caspase 1 Homo sapiens 30-33 8972182-4 1997 Fas has been shown to require ICE (interleukin-1 beta-converting enzyme) family proteases to induce apoptosis from studies utilizing the cowpox ICE inhibitor protein CrmA, the synthetic tetrapeptide ICE inhibitor YVAD-CMK, and the tripeptide pan-ICE inhibitor Z-VAD-FMK. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 260-269 caspase 1 Homo sapiens 35-71 8879205-5 1996 This apoptosis-inducing factor (AIF) is blocked by N-benzyloxycarbonyl-Val-Ala-Asp.fluoromethylketone (Z-VAD.fmk), an antagonist of interleukin-1 beta-converting enzyme (ICE)-like proteases that is also an efficient inhibitor of apoptosis in cells. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 103-112 caspase 1 Homo sapiens 132-168 8647264-7 1996 A tripeptide inhibitor of ICE family cysteine proteases, Z-Val-Ala-Asp-fluoromethylketone (zVAD-fmk) inhibits ionomycin- and AgR-triggered CPP32 activation, PARP cleavage and apoptosis, but not growth arrest, in Ramos-BL B cells. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 57-89 caspase 1 Homo sapiens 26-29 8647264-7 1996 A tripeptide inhibitor of ICE family cysteine proteases, Z-Val-Ala-Asp-fluoromethylketone (zVAD-fmk) inhibits ionomycin- and AgR-triggered CPP32 activation, PARP cleavage and apoptosis, but not growth arrest, in Ramos-BL B cells. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 91-99 caspase 1 Homo sapiens 26-29 8670109-2 1996 We now demonstrate that benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK), an ICE-like protease inhibitor, inhibits apoptosis by preventing the processing of CPP32 to its active form. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 80-89 caspase 1 Homo sapiens 95-98 8656677-6 1996 An inhibitor of interleukin 1-beta-converting enzyme (ICE), Z-Val-Ala-Asp-fluoromethyl ketone (VAD-FMK), had no effect on this DNA fragmenting activity in vitro. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 60-93 caspase 1 Homo sapiens 16-52 8656677-6 1996 An inhibitor of interleukin 1-beta-converting enzyme (ICE), Z-Val-Ala-Asp-fluoromethyl ketone (VAD-FMK), had no effect on this DNA fragmenting activity in vitro. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 60-93 caspase 1 Homo sapiens 54-57 34356509-4 2021 The pan-caspase inhibitor, z-VAD-fmk, and the caspase-1 inhibitor, z-YVAD-fmk, but not the JNK inhibitor, SP600125, significantly reversed apoptosis and caspase activation in TNF-alpha/MCPIP1-treated cells. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 27-36 caspase 1 Homo sapiens 8-15 34356509-4 2021 The pan-caspase inhibitor, z-VAD-fmk, and the caspase-1 inhibitor, z-YVAD-fmk, but not the JNK inhibitor, SP600125, significantly reversed apoptosis and caspase activation in TNF-alpha/MCPIP1-treated cells. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 27-36 caspase 1 Homo sapiens 153-160 24330827-8 2013 Cultured human microglia displayed expression of inflammasome-associated genes and responded to inflammasome activators by releasing IL-1beta, which was inhibited by the caspase inhibitor, zVAD-fmk. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 189-197 caspase 1 Homo sapiens 170-177 35238869-6 2022 Proteasome (bortezomib, MG132) and caspase-1 (VX-765, Z-VAD-FMK) inhibitors block NLRP1 activation and downstream pyroptosis, respectively. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 54-63 caspase 1 Homo sapiens 35-44 33043385-3 2021 SKOV3 cells and HeLa cells were pretreated with caspase inhibitor z-VAD-fmk for 30 min and then exposed to different doses of cardamonin and cisplatin, respectively. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 66-75 caspase 1 Homo sapiens 48-55 25281528-6 2014 Moreover, the silencing of the Nlrp3 gene or the use of the caspase-1 inhibitor Z-VAD-fmk significantly attenuated the albumin-induced increase in IL-1beta and IL-18 expression in HK2 cells. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 80-89 caspase 1 Homo sapiens 60-69 24925806-6 2014 While several inhibitors are available for caspase-1 blocking experiments, in this study we show effects of two commonly used caspase inhibitors: z-VAD-fmk and ac-YVAD-cmk on secretion of pro-inflammatory cytokines: IL-1beta, TNFalpha, IL-8 and IL-6 in whole blood stimulated with LPS. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 146-155 caspase 1 Homo sapiens 43-52