PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29267220-11	2017	In vitro, galangin markedly inhibited LPS-induced expression of tumor necrosis factor alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-1beta (IL-1beta), cyclooxygenase 2 (COX-2), and induced nitric oxide synthase (iNOS) via associating with the phosphorylation of c-JUN N-terminal Kinase (JNK), p38, protein kinase B (AKT), and nuclear factor kappaB (NF-kappaB) p65.	galangin	10-18	AKT serine/threonine kinase 1	Rattus norvegicus	325-328	
35157909-4	2022	In addition, omarigliptin and/or galangin significantly reduced the levels of phospho-Akt and glycogen synthase kinase 3 beta (GSK-3beta) and significantly increased the expression of beclin-1 in the cerebral tissues compared versus the group treated with LPS alone.	galangin	33-41	AKT serine/threonine kinase 1	Rattus norvegicus	86-89	
34090897-8	2021	Furthermore, GAL significantly suppressed IL-1beta-induced Akt phosphorylation and NF-kappaB activation in rat chondrocytes.	galangin	13-16	AKT serine/threonine kinase 1	Rattus norvegicus	59-62	
35157909-0	2022	Omarigliptin/galangin combination mitigates lipopolysaccharide-induced neuroinflammation in rats: Involvement of glucagon-like peptide-1, toll-like receptor-4, apoptosis and Akt/GSK-3beta signaling.	galangin	13-21	AKT serine/threonine kinase 1	Rattus norvegicus	174-177	
30628698-0	2019	Galangin decreases p-tau, Abeta42 and beta-secretase levels, and suppresses autophagy in okadaic acid-induced PC12 cells via an Akt/GSK3beta/mTOR signaling-dependent mechanism.	galangin	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	128-131	
33328989-9	2020	In addition, GA treatment modulates ISO-induced alterations the expressions of tissue inhibitor of metalloproteinases-1 (TIMP-1), p-AKT, glycogen synthase kinase-3beta (p-GSK-3beta) and peroxisome proliferators-activated receptor-gamma (PPAR-gamma) in the heart tissue.	galangin	13-15	AKT serine/threonine kinase 1	Rattus norvegicus	132-135	
30628698-10	2019	These results indicated that galangin protected PC12 cells from OA-induced cytotoxicity and inhibited autophagy via the Akt/GSK3beta/mTOR pathway, thus suggesting that it may be considered a potential therapeutic agent for AD.	galangin	29-37	AKT serine/threonine kinase 1	Rattus norvegicus	120-123	
35485325-10	2022	Galangin inactivated the PI3K/AKT signaling pathway and the inflammatory response.	galangin	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	30-33	
35485325-13	2022	Galangin effected its anti-arthritic influence through the PI3K/AKT signaling pathway.	galangin	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	64-67	
31240210-7	2019	Moreover, western blotting showed that galangin treatment effectively inhibited nuclear factor-kappa B (NF-kappaB), phosphatidylinositol 3 kinase (PI3K)/protein kinase B (AKT) and nucleotide-binding domain- (NOD-) like receptor protein 3 (NLRP3) signaling pathway activation.	galangin	39-47	AKT serine/threonine kinase 1	Rattus norvegicus	171-174	
31240210-8	2019	Taken together, these findings suggested that galangin plays a pivotal role in renal inflammation by suppressing inflammatory responses, which might be closely associated with the inhibition of NLRP3 inflammasome, NF-kappaB and PI3K/AKT signaling pathway activation.	galangin	46-54	AKT serine/threonine kinase 1	Rattus norvegicus	233-236